Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2817759..2817968 Replicon chromosome
Accession NZ_CP019857
Organism Clostridioides difficile strain DSM 29745

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CDIF29745_RS13610 Protein ID WP_004454815.1
Coordinates 2817810..2817968 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2817759..2817893 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF29745_RS13595 2813248..2814876 + 1629 WP_009897704.1 aspartate 4-decarboxylase -
CDIF29745_RS13600 2814997..2815992 + 996 WP_003431031.1 asparaginase -
CDIF29745_RS13605 2816181..2816564 - 384 Protein_2537 BlaI/MecI/CopY family transcriptional regulator -
- 2817759..2817893 + 135 NuclAT_0 - Antitoxin
CDIF29745_RS13610 2817810..2817968 - 159 WP_004454815.1 hypothetical protein Toxin
CDIF29745_RS13615 2818327..2819697 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
CDIF29745_RS13620 2819980..2820078 + 99 Protein_2540 Arm DNA-binding domain-containing protein -
CDIF29745_RS13625 2820097..2820518 + 422 Protein_2541 hypothetical protein -
CDIF29745_RS13630 2820749..2821021 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
CDIF29745_RS13635 2821384..2821464 - 81 Protein_2543 VOC family protein -
CDIF29745_RS13640 2821504..2822172 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T73341 WP_004454815.1 NZ_CP019857:c2817968-2817810 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T73341 NZ_CP019857:c2817968-2817810 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT73341 NZ_CP019857:2817759-2817893 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References