Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 51554..52293 Replicon plasmid pASM1
Accession NZ_CP019840
Organism Enterobacter roggenkampii strain R11

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag B1H21_RS23470 Protein ID WP_013087269.1
Coordinates 51554..52039 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag B1H21_RS23475 Protein ID WP_007869691.1
Coordinates 52027..52293 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1H21_RS23435 47057..48037 - 981 WP_000019445.1 IS5-like element ISKpn26 family transposase -
B1H21_RS23440 48108..48737 - 630 Protein_55 IS30-like element IS30 family transposase -
B1H21_RS23450 48802..49398 + 597 Protein_56 IS3 family transposase -
B1H21_RS23460 49680..49907 + 228 Protein_57 transposase -
B1H21_RS23465 50002..51347 - 1346 Protein_58 ISNCY family transposase -
B1H21_RS23470 51554..52039 - 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
B1H21_RS23475 52027..52293 - 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
B1H21_RS23485 52946..53959 + 1014 WP_059359379.1 replication initiation protein -
B1H21_RS23490 54808..55041 + 234 WP_008502220.1 DUF2767 family protein -
B1H21_RS23495 55063..55830 - 768 WP_008502221.1 conjugal transfer protein TraX -
B1H21_RS23505 56164..56406 - 243 WP_008502222.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..85262 85262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T73334 WP_013087269.1 NZ_CP019840:c52039-51554 [Enterobacter roggenkampii]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T73334 NZ_CP019840:c52039-51554 [Enterobacter roggenkampii]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT73334 WP_007869691.1 NZ_CP019840:c52293-52027 [Enterobacter roggenkampii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT73334 NZ_CP019840:c52293-52027 [Enterobacter roggenkampii]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References