Detailed information of TA system TA073201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 367904..368530
• Replicon: chromosome
• Accession: NZ_CP019706
• Organism: Pantoea alhagi strain LTYR-11Z

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A2K1QC31
• Locus tag: B1H58_RS01765
• Protein ID: WP_071883698.1
• Coordinates: 368312..368530 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: B1H58_RS01760
• Protein ID: WP_085067696.1
• Coordinates: 367904..368284 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B1H58_RS01740	363310..366459	+	3150	WP_085067692.1	multidrug efflux RND transporter permease subunit AcrB	-
B1H58_RS01745	366645..366902	+	258	WP_085067693.1	type B 50S ribosomal protein L31	-
B1H58_RS01750	366918..367058	+	141	WP_085067694.1	type B 50S ribosomal protein L36	-
B1H58_RS01755	367402..367755	+	354	WP_157130133.1	hypothetical protein	-
B1H58_RS01760	367904..368284	+	381	WP_085067696.1	Hha toxicity modulator TomB	Antitoxin
B1H58_RS01765	368312..368530	+	219	WP_071883698.1	hemolysin expression modulator Hha	Toxin
B1H58_RS01775	368877..369185	+	309	WP_085067697.1	MGMT family protein	-
B1H58_RS01780	369217..369771	-	555	WP_085067698.1	YbaY family lipoprotein	-
B1H58_RS01785	369986..370846	+	861	WP_085067699.1	acyl-CoA thioesterase II	-
B1H58_RS01790	370901..372184	-	1284	WP_085067700.1	ammonium transporter AmtB	-
B1H58_RS01795	372220..372558	-	339	WP_007886947.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8701.16 Da
• Isoelectric Point: 8.8578

>T73201 WP_071883698.1 NZ_CP019706:368312-368530 [Pantoea alhagi]
MTEKIMTKTDYLMRLRRCRSIDTLERVIEKNKYELPDDELAVFYSAADHRLAELTMNKLYDKVPVSVWKYVR

Nucleotide

• Length: 219 bp

>T73201 NZ_CP019706:368312-368530 [Pantoea alhagi]
ATGACAGAAAAAATTATGACCAAGACTGACTATCTGATGCGCTTAAGACGTTGCCGATCCATTGATACACTTGAGCGTGT
TATTGAAAAGAATAAATATGAATTACCTGATGATGAACTGGCTGTTTTTTATTCCGCAGCGGATCATCGTCTGGCTGAAT
TAACAATGAATAAGCTGTACGATAAAGTCCCAGTATCAGTATGGAAATATGTACGCTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14727.33 Da
• Isoelectric Point: 4.2930

>AT73201 WP_085067696.1 NZ_CP019706:367904-368284 [Pantoea alhagi]
MDEYSPKRHDIAQLNFLCENLYDESMATLGDSHHGWVNDPTSASNLQLNDLIEHIASFTMNYKIKHAEDEDLIVQIDDYL
DDTFMLFSNYGINVQDLQRWQRSARRLFNLFAEECAQLPLQPSHSF

Nucleotide

• Length: 381 bp

>AT73201 NZ_CP019706:367904-368284 [Pantoea alhagi]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGTTGAATTTCTTGTGTGAGAATCTGTACGACGAAAGTATGGC
AACGTTAGGTGACAGCCATCATGGCTGGGTTAATGATCCTACGTCCGCTTCTAATTTACAACTGAATGATCTGATTGAAC
ATATTGCTTCATTCACGATGAATTATAAAATTAAGCATGCTGAGGATGAGGATCTCATTGTTCAAATTGATGATTACCTC
GATGATACCTTTATGCTTTTCAGTAATTACGGCATCAATGTTCAGGACCTACAGCGCTGGCAGCGTTCCGCCCGACGTTT
GTTTAACCTTTTCGCAGAAGAGTGCGCTCAGCTTCCTTTACAGCCAAGCCATTCATTTTAG

Structures

Toxin

• AlphaFold DB: A0A2K1QC31