Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 167647..168286 Replicon chromosome
Accession NZ_CP019668
Organism Burkholderia cenocepacia strain VC7848

Toxin (Protein)


Gene name vapC Uniprot ID A0A3N9F707
Locus tag A8E88_RS00770 Protein ID WP_011547639.1
Coordinates 167876..168286 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1K469
Locus tag A8E88_RS00765 Protein ID WP_011547638.1
Coordinates 167647..167883 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8E88_RS35145 162964..163284 + 321 WP_166488159.1 hypothetical protein -
A8E88_RS00745 163394..164083 - 690 WP_171984323.1 hypothetical protein -
A8E88_RS35150 164653..164874 - 222 WP_027811879.1 hypothetical protein -
A8E88_RS00755 165233..165910 + 678 WP_012339913.1 hypothetical protein -
A8E88_RS00760 165930..167156 - 1227 WP_012339914.1 acyltransferase -
A8E88_RS00765 167647..167883 + 237 WP_011547638.1 DNA-binding protein Antitoxin
A8E88_RS00770 167876..168286 + 411 WP_011547639.1 type II toxin-antitoxin system VapC family toxin Toxin
A8E88_RS00775 168700..168903 + 204 WP_006483056.1 cold-shock protein -
A8E88_RS00785 169370..169633 + 264 WP_006483034.1 translation initiation factor IF-1 -
A8E88_RS00795 170203..171450 + 1248 WP_011547640.1 alkaline phosphatase family protein -
A8E88_RS00800 171447..171695 + 249 WP_011547641.1 hypothetical protein -
A8E88_RS00805 172145..172393 + 249 WP_006478971.1 hypothetical protein -
A8E88_RS00810 172605..172904 + 300 WP_011547642.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15202.37 Da        Isoelectric Point: 6.8816

>T73130 WP_011547639.1 NZ_CP019668:167876-168286 [Burkholderia cenocepacia]
MIDTNVISEIRKGRRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWIAMILSGYAPNILP
VDIETSQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Download         Length: 411 bp

>T73130 NZ_CP019668:167876-168286 [Burkholderia cenocepacia]
TTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAGGCGAACCAATCGCGGCGTGCGGGCGTTCTTCAGGCAGGC
CGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGTTGCGGCGCGGCGTCGACCTGATCCGTCATC
GCGGCGATCATAGCCAGGCGTCGGCGCTCGAGGCCTGGATCGCGATGATCCTGTCGGGCTATGCGCCGAACATCCTGCCG
GTCGATATCGAGACCAGCCAGATGTGGGGGCATTTGCGGGTGCCCGATCCGACGCACGAACTCGACAAGCTGATCGCGGC
CACCGCGCTGATCAACGATCTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACTGGCGTCCGGTTGCTGAATC
CGTTCGACTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8692.75 Da        Isoelectric Point: 5.0916

>AT73130 WP_011547638.1 NZ_CP019668:167647-167883 [Burkholderia cenocepacia]
MANLLVRNVDDTIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLLSMPEVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT73130 NZ_CP019668:167647-167883 [Burkholderia cenocepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTATCGTTCAAAGCCTGCGTGAGCAGGCGGCGGCCAATGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGGACATTTGCTCAAGTGCTGCTGA
GCATGCCGGAGGTGGGCGAGGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N9F707

Antitoxin

Source ID Structure
AlphaFold DB B1K469

References