Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2841951..2842599 Replicon chromosome
Accession NZ_CP019612
Organism Mycobacterium tuberculosis strain H107

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag B0W96_RS13895 Protein ID WP_003899414.1
Coordinates 2841951..2842274 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag B0W96_RS13900 Protein ID WP_003899415.1
Coordinates 2842354..2842599 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W96_RS13865 2837274..2838272 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
B0W96_RS13870 2838286..2838750 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
B0W96_RS13875 2838738..2838989 + 252 WP_003908028.1 hypothetical protein -
B0W96_RS13880 2839160..2840599 - 1440 WP_003899411.1 phage major capsid protein -
B0W96_RS13885 2840607..2841140 - 534 WP_003899412.1 HK97 family phage prohead protease -
B0W96_RS13890 2841293..2841919 - 627 WP_003899413.1 phage terminase small subunit P27 family -
B0W96_RS13895 2841951..2842274 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
B0W96_RS13900 2842354..2842599 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
B0W96_RS13905 2842596..2844023 - 1428 WP_031664026.1 DUF3631 domain-containing protein -
B0W96_RS13910 2844025..2844417 - 393 WP_003899417.1 DUF2742 domain-containing protein -
B0W96_RS13915 2844414..2844674 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
B0W96_RS13920 2844691..2845053 - 363 WP_003900543.1 hypothetical protein -
B0W96_RS13925 2845056..2846183 - 1128 WP_003899420.1 site-specific integrase -
B0W96_RS13930 2846328..2846555 - 228 WP_003899421.1 hypothetical protein -
B0W96_RS13935 2846552..2846941 - 390 WP_003899422.1 hypothetical protein -
B0W96_RS13940 2846847..2847119 + 273 WP_003900544.1 hypothetical protein -
B0W96_RS13945 2847218..2847451 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2836846..2846183 9337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T72983 WP_003899414.1 NZ_CP019612:c2842274-2841951 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T72983 NZ_CP019612:c2842274-2841951 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT72983 WP_003899415.1 NZ_CP019612:c2842599-2842354 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT72983 NZ_CP019612:c2842599-2842354 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References