Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2205420..2206255 Replicon chromosome
Accession NZ_CP019280
Organism Escherichia coli strain 13P484A

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2T3T4L0
Locus tag BWI90_RS11805 Protein ID WP_001556084.1
Coordinates 2205878..2206255 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A403D757
Locus tag BWI90_RS11800 Protein ID WP_016230789.1
Coordinates 2205420..2205788 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWI90_RS11765 2202535..2202693 + 159 WP_001323397.1 DUF905 family protein -
BWI90_RS11775 2202848..2203666 + 819 WP_020239663.1 DUF945 domain-containing protein -
BWI90_RS11785 2204008..2204481 + 474 WP_001765426.1 antirestriction protein -
BWI90_RS11790 2204497..2204973 + 477 WP_001186775.1 RadC family protein -
BWI90_RS11795 2205036..2205257 + 222 WP_000692345.1 DUF987 domain-containing protein -
BWI90_RS11800 2205420..2205788 + 369 WP_016230789.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BWI90_RS11805 2205878..2206255 + 378 WP_001556084.1 TA system toxin CbtA family protein Toxin
BWI90_RS11810 2206252..2206455 + 204 WP_000761705.1 hypothetical protein -
BWI90_RS27815 2206468..2206581 + 114 WP_032140621.1 DUF957 domain-containing protein -
BWI90_RS27820 2207379..2207768 + 390 WP_102804527.1 transposase -
BWI90_RS11825 2208222..2208404 + 183 WP_024174802.1 ethanolamine utilization protein -
BWI90_RS11830 2208505..2208834 - 330 WP_000450409.1 DUF496 family protein -
BWI90_RS11835 2209006..2210064 - 1059 WP_001200895.1 FUSC family protein -
BWI90_RS11840 2210262..2210735 - 474 WP_001105407.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14232.27 Da        Isoelectric Point: 7.8276

>T72200 WP_001556084.1 NZ_CP019280:2205878-2206255 [Escherichia coli]
MKTLPDTHVRELSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T72200 NZ_CP019280:2205878-2206255 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGTTATCGCGCTGCCCATCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13614.45 Da        Isoelectric Point: 7.0264

>AT72200 WP_016230789.1 NZ_CP019280:2205420-2205788 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT72200 NZ_CP019280:2205420-2205788 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3T4L0

Antitoxin

Source ID Structure
AlphaFold DB A0A403D757

References