Detailed information of TA system TA071888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3756890..3757490
• Replicon: chromosome
• Accession: NZ_CP019239
• Organism: Rhodoferax saidenbachensis strain DSM 22694

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: RS694_RS17900
• Protein ID: WP_076069882.1
• Coordinates: 3756890..3757249 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1P8KDY7
• Locus tag: RS694_RS17905
• Protein ID: WP_029705280.1
• Coordinates: 3757236..3757490 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RS694_RS17885	3752428..3754374	-	1947	WP_029705287.1	AMP-binding protein	-
RS694_RS17890	3754566..3755282	+	717	WP_029705286.1	Crp/Fnr family transcriptional regulator	-
RS694_RS17895	3755671..3756675	+	1005	WP_051391617.1	toll/interleukin-1 receptor domain-containing protein	-
RS694_RS17900	3756890..3757249	-	360	WP_076069882.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RS694_RS17905	3757236..3757490	-	255	WP_029705280.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
RS694_RS17910	3757826..3758575	+	750	WP_161631539.1	transporter substrate-binding domain-containing protein	-
RS694_RS17915	3758583..3759035	-	453	WP_029705276.1	STAS/SEC14 domain-containing protein	-
RS694_RS20560	3759321..3759485	+	165	WP_156876177.1	hypothetical protein	-
RS694_RS17920	3759569..3761347	-	1779	WP_029705275.1	MCP four helix bundle domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-69)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13604.83 Da
• Isoelectric Point: 10.9283

>T71888 WP_076069882.1 NZ_CP019239:c3757249-3756890 [Rhodoferax saidenbachensis]
MKPYELEFDESALKEWRKLDGSIQSLFKKQLAKRLNAPHVPSARLHGDLQNTYKIKLRDAGYRLVYEVIDQRLVVVVIAV
GRRDQDAVYMQASKRLASLGGVTPQLKTVSRRRAKPARS

Nucleotide

• Length: 360 bp

>T71888 NZ_CP019239:c3757249-3756890 [Rhodoferax saidenbachensis]
TTGAAGCCCTATGAGCTTGAGTTTGACGAGTCCGCGCTCAAGGAGTGGCGCAAGCTCGATGGCTCTATCCAGAGTCTTTT
CAAGAAGCAACTGGCCAAGCGCCTGAACGCTCCGCACGTTCCCTCCGCCCGGCTACATGGCGATCTGCAAAACACCTACA
AAATCAAACTTCGCGATGCGGGGTATCGCCTGGTTTACGAAGTGATCGACCAGCGCCTGGTGGTTGTAGTCATCGCTGTG
GGTCGGCGGGACCAGGACGCGGTCTATATGCAAGCTAGCAAGCGTCTTGCATCGTTGGGCGGAGTTACTCCGCAGTTGAA
AACTGTGTCCCGACGCAGAGCAAAACCTGCTCGAAGTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9119.47 Da
• Isoelectric Point: 8.5150

>AT71888 WP_029705280.1 NZ_CP019239:c3757490-3757236 [Rhodoferax saidenbachensis]
MAATHAIYAQTTVSMTDLRRNPSGILEDAGDSPIAVLNHNKPAAYLLSAKAYEALLDRLDDAELTKIVKQRQGGKRVKVT
LEAL

Nucleotide

• Length: 255 bp

>AT71888 NZ_CP019239:c3757490-3757236 [Rhodoferax saidenbachensis]
ATGGCAGCAACCCACGCAATCTATGCCCAAACGACGGTCAGCATGACGGACCTGCGGCGCAATCCCAGCGGCATTCTGGA
AGACGCGGGTGATTCGCCCATTGCGGTGTTGAACCACAACAAACCCGCCGCTTACCTGCTCTCGGCCAAAGCCTATGAGG
CTTTGCTGGACAGGCTTGACGACGCGGAGCTGACCAAAATTGTGAAGCAGCGGCAAGGTGGCAAACGGGTCAAGGTGACA
CTTGAAGCCCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A1P8KDY7