Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1138691..1139374 Replicon chromosome
Accession NZ_CP019221
Organism Mycobacterium intracellulare subsp. chimaera strain CDC 2015-22-71 isolate PA-Patient

Toxin (Protein)


Gene name vapC Uniprot ID D5PEA4
Locus tag BWK49_RS05620 Protein ID WP_007168487.1
Coordinates 1138691..1139098 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1XBB9
Locus tag BWK49_RS05625 Protein ID WP_033711258.1
Coordinates 1139102..1139374 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWK49_RS29815 1133972..1134187 + 216 WP_158514285.1 hypothetical protein -
BWK49_RS29820 1134126..1134371 + 246 WP_080711236.1 hypothetical protein -
BWK49_RS05595 1134347..1134658 + 312 WP_075362207.1 transposase -
BWK49_RS05600 1134674..1135927 + 1254 WP_101930934.1 IS30 family transposase -
BWK49_RS05605 1136044..1136214 - 171 Protein_1104 carnitinyl-CoA dehydratase -
BWK49_RS05610 1137963..1138268 - 306 WP_007168485.1 hypothetical protein -
BWK49_RS05615 1138329..1138670 - 342 WP_007168486.1 hypothetical protein -
BWK49_RS05620 1138691..1139098 - 408 WP_007168487.1 type II toxin-antitoxin system VapC family toxin Toxin
BWK49_RS05625 1139102..1139374 - 273 WP_033711258.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BWK49_RS05635 1139870..1141105 - 1236 WP_042909886.1 IS256 family transposase -
BWK49_RS29370 1141747..1141932 + 186 WP_132160383.1 hypothetical protein -
BWK49_RS05640 1142006..1142422 - 417 WP_007168492.1 type II toxin-antitoxin system VapC family toxin -
BWK49_RS05645 1142419..1142670 - 252 WP_007168493.1 ribbon-helix-helix protein, CopG family -
BWK49_RS05655 1143472..1143867 + 396 WP_007168495.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1118049..1160683 42634
- flank IS/Tn - - 1139870..1141105 1235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14464.55 Da        Isoelectric Point: 4.6697

>T71856 WP_007168487.1 NZ_CP019221:c1139098-1138691 [Mycobacterium intracellulare subsp. chimaera]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS

Download         Length: 408 bp

>T71856 NZ_CP019221:c1139098-1138691 [Mycobacterium intracellulare subsp. chimaera]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9764.35 Da        Isoelectric Point: 8.7382

>AT71856 WP_033711258.1 NZ_CP019221:c1139374-1139102 [Mycobacterium intracellulare subsp. chimaera]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY

Download         Length: 273 bp

>AT71856 NZ_CP019221:c1139374-1139102 [Mycobacterium intracellulare subsp. chimaera]
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XAJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XBB9

References