Detailed information of TA system TA071812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 23137..23659
• Replicon: plasmid pATCC39184
• Accession: NZ_CP019180
• Organism: Salmonella enterica subsp. enterica serovar Dublin str. ATCC 39184

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: BWD35_RS24735
• Protein ID: WP_000220560.1
• Coordinates: 23137..23418 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: BWD35_RS24740
• Protein ID: WP_000121743.1
• Coordinates: 23408..23659 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWD35_RS24695	18970..20151	-	1182	WP_000539536.1	relaxase/mobilization nuclease domain-containing protein	-
BWD35_RS24700	20154..20699	-	546	WP_000757691.1	hypothetical protein	-
BWD35_RS25920	20694..20768	-	75	Protein_24	DNA distortion polypeptide 3	-
BWD35_RS24705	21025..21297	-	273	WP_000160399.1	hypothetical protein	-
BWD35_RS25925	21310..21459	-	150	WP_000003880.1	hypothetical protein	-
BWD35_RS24710	21529..21708	-	180	WP_001575529.1	hypothetical protein	-
BWD35_RS24715	21751..22080	-	330	WP_000866650.1	hypothetical protein	-
BWD35_RS24720	22173..22388	-	216	WP_001180117.1	hypothetical protein	-
BWD35_RS24725	22378..22623	-	246	WP_000356542.1	hypothetical protein	-
BWD35_RS24730	22668..22991	-	324	WP_001181909.1	hypothetical protein	-
BWD35_RS24735	23137..23418	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BWD35_RS24740	23408..23659	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
BWD35_RS24750	24895..25731	+	837	WP_001575533.1	replication initiation protein	-
BWD35_RS24755	25771..26217	+	447	WP_001074381.1	hypothetical protein	-
BWD35_RS24760	26285..26707	+	423	WP_000202949.1	hypothetical protein	-
BWD35_RS24770	27346..27576	-	231	WP_000051066.1	partitioning protein	-
BWD35_RS24775	27628..28248	-	621	WP_000864788.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74560	74560

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (16-56)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T71812 WP_000220560.1 NZ_CP019180:c23418-23137 [Salmonella enterica subsp. enterica serovar Dublin str. ATCC 39184]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T71812 NZ_CP019180:c23418-23137 [Salmonella enterica subsp. enterica serovar Dublin str. ATCC 39184]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT71812 WP_000121743.1 NZ_CP019180:c23659-23408 [Salmonella enterica subsp. enterica serovar Dublin str. ATCC 39184]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT71812 NZ_CP019180:c23659-23408 [Salmonella enterica subsp. enterica serovar Dublin str. ATCC 39184]
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Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301