Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5070669..5072292 Replicon chromosome
Accession NZ_CP018929
Organism Serratia marcescens strain UMH11

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BVG89_RS23955 Protein ID WP_089181609.1
Coordinates 5070970..5072292 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BVG89_RS23950 Protein ID WP_089181608.1
Coordinates 5070669..5070965 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG89_RS23945 5065721..5069350 - 3630 WP_089181607.1 DNA helicase -
BVG89_RS23950 5070669..5070965 + 297 WP_089181608.1 helix-turn-helix transcriptional regulator Antitoxin
BVG89_RS23955 5070970..5072292 + 1323 WP_089181609.1 type II toxin-antitoxin system HipA family toxin Toxin
BVG89_RS23960 5072507..5076109 - 3603 WP_089181717.1 hypothetical protein -
BVG89_RS23965 5076353..5076532 + 180 Protein_4662 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49838.92 Da        Isoelectric Point: 6.2359

>T70936 WP_089181609.1 NZ_CP018929:5070970-5072292 [Serratia marcescens]
MRRSQQRLAIWMNGIPVGYWEKRKGEDRLEYLPEWIADSQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AMRYHADSLDPFDLLAELGRDCVGAIQLLDIGEQPADIFSIRQRPLAEAQIAEMLRNTATTLPGLQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMRTSIENEWLCSMIVEHYGVPVASTHIAQFEDQKALIVERFD
RKLSSDKQWWIRLPQEDMCQALGVSPLRKYQSDGGPGITDIMEILSRSEQAETDRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNNQIAWQKCKLAMAVRGSSNHYLLSQIRRRHWIKHGEITGLGQQEVESIIEELL
AATPGVIDCVIGLLPDSFPAELAECIFDGIRQQCARLAGR

Download         Length: 1323 bp

>T70936 NZ_CP018929:5070970-5072292 [Serratia marcescens]
ATGCGTCGTTCGCAACAACGGTTAGCTATCTGGATGAACGGTATTCCGGTGGGATACTGGGAAAAGCGTAAAGGCGAAGA
TCGGCTGGAGTATCTGCCTGAGTGGATTGCAGATAGTCAGGGGAGGCCTTTGTCGCTTTCTTTGCCTTTCACGCCAGGGA
ATCAGCCTTATCGCGGTAGCGTGGTACGCGATTATTTCGATAACCTGCTGCCGGATAGTGAGGGGATCCGCCGACGTTTG
GCTATGCGCTATCATGCCGACAGTCTGGACCCTTTCGATTTATTGGCCGAACTGGGTCGCGACTGTGTTGGTGCCATACA
GCTTCTCGATATCGGTGAGCAACCTGCTGATATCTTTTCCATCAGGCAGCGTCCGCTTGCAGAGGCGCAAATCGCCGAAA
TGCTCCGCAATACTGCCACGACGTTACCGGGGCTGCAGGGACAGGATGACGATCTGCGTTTATCCATCGCCGGCGCTCAG
GAAAAAACGGCGCTGCTGTGGCATGACAACCAGTGGTGTTTACCTGAGGGAAATACGCCGACCACGCATATTTTCAAATT
AGCGCTAGGCCTGGTGGGAAACATGCGGGCCGATATGCGCACGTCCATCGAGAATGAATGGCTCTGCTCCATGATTGTTG
AACACTATGGTGTGCCGGTAGCAAGTACCCATATTGCGCAGTTTGAAGATCAAAAGGCACTGATCGTTGAGCGTTTTGAC
AGAAAATTATCAAGCGACAAACAGTGGTGGATCCGCCTGCCGCAAGAGGATATGTGCCAGGCTCTGGGCGTTTCGCCGCT
GAGGAAGTATCAATCAGATGGTGGCCCCGGTATTACCGATATTATGGAAATTCTGAGTCGCTCGGAACAGGCTGAAACAG
ATCGCAGGCACTTCTTTAAAGCGCAGATTATTTTTTGGCTGCTGGCCGCGACAGATGGCCACGCAAAGAATTTCAGTCTT
GCACATTTACCGCAAAATCGTTACCACCTGACGCCATTGTACGATGTGCTATCGGCCTGGCCGCTGATTGGCCCGGGTAA
TAACCAGATAGCCTGGCAGAAGTGCAAACTGGCGATGGCCGTTCGCGGGAGCAGTAACCATTACCTGCTTAGCCAGATCC
GACGCCGCCACTGGATAAAACACGGTGAAATAACTGGGTTAGGCCAACAGGAGGTTGAATCCATTATTGAAGAGCTGCTG
GCAGCAACCCCGGGAGTGATTGATTGTGTCATTGGACTGCTACCTGATTCGTTCCCAGCCGAATTAGCGGAATGCATTTT
TGATGGTATCAGGCAGCAGTGCGCGCGGTTGGCAGGGCGATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11021.61 Da        Isoelectric Point: 8.0100

>AT70936 WP_089181608.1 NZ_CP018929:5070669-5070965 [Serratia marcescens]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEIVFSSELASPGCE
TEEISTIHIDSPARREQW

Download         Length: 297 bp

>AT70936 NZ_CP018929:5070669-5070965 [Serratia marcescens]
ATGAATACCGTCTATCCGTTAAAAACACTGAGCCAGCTACGCCCTTTGCTGGTGGGGTTTCGTAAAGCAAAAGGTCTGAC
GCAAAAAGACGTTTCGGAGAGGCTGGGCGTCACTCAACAGACCTATGCGCGCCTGGAGTCAAACCCTGCATCAGCCAGTC
TGGAGCGCCTTTTTAGGGTGTTTAATGTGCTGGGGATTGAAATTGTGTTTTCCTCAGAGCTTGCCTCTCCGGGATGTGAA
ACGGAAGAAATCTCTACAATTCATATAGACTCGCCGGCAAGACGGGAACAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References