Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4515161..4515762 Replicon chromosome
Accession NZ_CP018929
Organism Serratia marcescens strain UMH11

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag BVG89_RS21415 Protein ID WP_025304766.1
Coordinates 4515161..4515541 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag BVG89_RS21420 Protein ID WP_025304767.1
Coordinates 4515541..4515762 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG89_RS21390 4510408..4511688 + 1281 WP_089181467.1 DUF3748 domain-containing protein -
BVG89_RS21395 4511719..4512066 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
BVG89_RS21400 4512376..4512789 + 414 WP_004933919.1 heat shock chaperone IbpA -
BVG89_RS21405 4512896..4513324 + 429 WP_004933922.1 heat shock chaperone IbpB -
BVG89_RS21410 4513492..4515150 + 1659 WP_089181468.1 putative transporter -
BVG89_RS21415 4515161..4515541 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
BVG89_RS21420 4515541..4515762 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
BVG89_RS21425 4515837..4517087 - 1251 WP_089181469.1 valine--pyruvate transaminase -
BVG89_RS21430 4517223..4519286 - 2064 WP_089181470.1 alpha-amylase -
BVG89_RS25025 4519483..4519635 + 153 WP_162837931.1 hypothetical protein -
BVG89_RS21435 4519637..4520614 - 978 WP_089181471.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T70935 WP_025304766.1 NZ_CP018929:c4515541-4515161 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T70935 NZ_CP018929:c4515541-4515161 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAGGGACGTTCT
GGTCGAGTATCACATCAATCCGGCCATCAGCGCCATCACCTGGATGGAAGTGATGGTAGGTGCTAAAAAACAGGGTCCGG
CACTGGAGCTGAAAACACGTCAGTTTTTAGGGCAATTTCTGCTGCTGCCTATTACCGATGAAGTCGCTGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAACTGCCAGACGCCATTATCTGGGCCACAGCGCAGGTGGGATTCCGGATGCTCAT
CTCCCGCAACCCCAAAGATTTCGGCACTGACAATGGCGTGTTGATGCCTTATCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT70935 WP_025304767.1 NZ_CP018929:c4515762-4515541 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT70935 NZ_CP018929:c4515762-4515541 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGATAATCTGAAAAATATCCGCCACGTTCCGCG
GGCCGAGATCATTCGTCAAGCAGTCTCCCGCTATCTGACGGAGAACCACGTGGAAGATCCCAGCAACGCTTTCGGGCTCT
GGTCCGGGGCGATGGGAGATGGCGTGGAGTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References