Detailed information of TA system TA070932

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 3484434..3485157
• Replicon: chromosome
• Accession: NZ_CP018929
• Organism: Serratia marcescens strain UMH11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BVG89_RS16580
• Protein ID: WP_049296187.1
• Coordinates: 3484434..3484820 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BVG89_RS16585
• Protein ID: WP_025304117.1
• Coordinates: 3484813..3485157 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG89_RS16570	3481547..3483064	-	1518	WP_004931697.1	lysine--tRNA ligase	-
BVG89_RS16580	3484434..3484820	+	387	WP_049296187.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BVG89_RS16585	3484813..3485157	+	345	WP_025304117.1	helix-turn-helix domain-containing protein	Antitoxin
BVG89_RS16590	3485208..3486941	-	1734	WP_016929971.1	single-stranded-DNA-specific exonuclease RecJ	-
BVG89_RS16595	3486948..3487664	-	717	WP_025304118.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
BVG89_RS16600	3487691..3488611	-	921	WP_154747450.1	site-specific tyrosine recombinase XerD	-
BVG89_RS16605	3488697..3489215	+	519	WP_033635825.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (54-91)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14614.65 Da
• Isoelectric Point: 9.4235

>T70932 WP_049296187.1 NZ_CP018929:3484434-3484820 [Serratia marcescens]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELAHGNHDGDLGGGVYKKRISLNRGKRGGARSIVAFKRGRHQYFIDGWLKNT
VKQNGAKEINDDELATYRELARDFLAMPPEIIKRAIDSGYLREVKCDD

Nucleotide

• Length: 387 bp

>T70932 NZ_CP018929:3484434-3484820 [Serratia marcescens]
ATGGACATTTTCGTCACGGATGATTTCGACAAATTTATGAAGAAAAATCGCATCGTCGATCAAAAGATTTGCACCGCGGC
TCACGAACTCGCACACGGTAACCATGACGGCGATCTGGGCGGCGGCGTCTACAAGAAACGTATTTCGCTCAATCGGGGTA
AACGGGGTGGCGCTCGATCCATCGTGGCGTTTAAACGCGGTCGTCATCAGTATTTTATTGATGGATGGCTGAAAAACACC
GTAAAACAGAACGGTGCAAAAGAAATCAACGATGATGAATTGGCAACCTATCGCGAGCTCGCCAGAGATTTTCTTGCCAT
GCCGCCGGAAATTATCAAACGAGCCATCGATAGCGGCTACTTGCGAGAGGTGAAATGCGATGACTGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12919.85 Da
• Isoelectric Point: 11.4121

>AT70932 WP_025304117.1 NZ_CP018929:3484813-3485157 [Serratia marcescens]
MTDNRLLRLQKMAQRFNEIGAVSDDTVRNIATRVQAQEQHAQREQHDQMDGARIKMLRRRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGAALRMLEIIEQKGVASLIISPRN

Nucleotide

• Length: 345 bp

>AT70932 NZ_CP018929:3484813-3485157 [Serratia marcescens]
ATGACTGATAATCGCCTGCTCAGACTGCAAAAAATGGCACAGCGTTTTAATGAGATCGGTGCGGTGTCAGACGATACCGT
ACGCAACATCGCCACACGAGTACAGGCGCAGGAACAACATGCCCAGCGTGAGCAGCATGATCAAATGGACGGCGCACGCA
TCAAAATGCTGCGCAGACGGCTTGGCTTGAGCCAGGCCGATTTAGCGGCCGTGGTCAACATGTCGACCACCAGCGTACAA
AAATGGGAACGTAACGCGGTAAAACCCCAGGGAGCCGCGCTCAGAATGCTGGAAATTATCGAACAGAAAGGGGTCGCCAG
CCTGATCATCTCACCACGAAACTGA