Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2687795..2688455 Replicon chromosome
Accession NZ_CP018929
Organism Serratia marcescens strain UMH11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BVG89_RS12840 Protein ID WP_089181114.1
Coordinates 2688102..2688455 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag BVG89_RS12835 Protein ID WP_016927038.1
Coordinates 2687795..2688097 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG89_RS12815 2683397..2684311 - 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -
BVG89_RS12820 2684437..2685555 - 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
BVG89_RS12830 2686161..2687369 - 1209 WP_060433584.1 aldose 1-epimerase family protein -
BVG89_RS12835 2687795..2688097 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
BVG89_RS12840 2688102..2688455 - 354 WP_089181114.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVG89_RS12845 2688894..2690189 + 1296 WP_089181115.1 MFS transporter -
BVG89_RS12850 2690216..2691022 + 807 WP_049203514.1 substrate-binding domain-containing protein -
BVG89_RS12855 2690997..2691896 - 900 WP_046896395.1 LysR family transcriptional regulator -
BVG89_RS12860 2692000..2692365 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13518.38 Da        Isoelectric Point: 9.4066

>T70928 WP_089181114.1 NZ_CP018929:c2688455-2688102 [Serratia marcescens]
VWEIKTTDAFDHWYRSLSDADRAGVLAALMALREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMLQIADREFTNWLNTLNEKE

Download         Length: 354 bp

>T70928 NZ_CP018929:c2688455-2688102 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTACAGATCGCTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGCCCTGCGGGAAAAGGGGCCGGGTCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGCAATGAAAAACGCTTTTACGATCGAATGCTTCAGATTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT70928 WP_016927038.1 NZ_CP018929:c2688097-2687795 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT70928 NZ_CP018929:c2688097-2687795 [Serratia marcescens]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATCGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References