Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 389398..390020 Replicon chromosome
Accession NZ_CP018929
Organism Serratia marcescens strain UMH11

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag BVG89_RS01855 Protein ID WP_004940313.1
Coordinates 389398..389601 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag BVG89_RS01860 Protein ID WP_004940312.1
Coordinates 389652..390020 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG89_RS01825 385097..385435 + 339 WP_004940327.1 P-II family nitrogen regulator -
BVG89_RS01830 385472..386758 + 1287 WP_038628958.1 ammonium transporter AmtB -
BVG89_RS01835 386849..387712 - 864 WP_016928847.1 acyl-CoA thioesterase II -
BVG89_RS01840 387944..388435 + 492 WP_025301777.1 YbaY family lipoprotein -
BVG89_RS01845 388500..388814 - 315 WP_025301778.1 MGMT family protein -
BVG89_RS01855 389398..389601 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
BVG89_RS01860 389652..390020 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
BVG89_RS01865 390179..390532 - 354 WP_025301779.1 hypothetical protein -
BVG89_RS01875 390941..391654 + 714 WP_060447642.1 ABC transporter ATP-binding protein -
BVG89_RS01880 391651..392508 + 858 WP_043135664.1 metal ABC transporter permease -
BVG89_RS01885 392534..393412 + 879 WP_025301782.1 metal ABC transporter substrate-binding protein -
BVG89_RS01890 393523..393663 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
BVG89_RS01895 393676..393930 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T70918 WP_004940313.1 NZ_CP018929:c389601-389398 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T70918 NZ_CP018929:c389601-389398 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT70918 WP_004940312.1 NZ_CP018929:c390020-389652 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT70918 NZ_CP018929:c390020-389652 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGCTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GATGATACCTATACGCTGTTCAGCAGTTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References