Detailed information of TA system TA070898

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4505655..4506190
• Replicon: chromosome
• Accession: NZ_CP018927
• Organism: Serratia marcescens strain UMH8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D971
• Locus tag: BVG90_RS21555
• Protein ID: WP_033636570.1
• Coordinates: 4505915..4506190 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2GBD7
• Locus tag: BVG90_RS21550
• Protein ID: WP_033639076.1
• Coordinates: 4505655..4505915 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG90_RS21530	4500981..4501631	+	651	WP_033639079.1	DcrB-related protein	-
BVG90_RS21535	4501667..4502272	+	606	WP_004934025.1	glutathione S-transferase	-
BVG90_RS21540	4502340..4503734	+	1395	WP_089185152.1	L-seryl-tRNA(Sec) selenium transferase	-
BVG90_RS21545	4503731..4505572	+	1842	WP_060444909.1	selenocysteine-specific translation elongation factor	-
BVG90_RS21550	4505655..4505915	+	261	WP_033639076.1	ribbon-helix-helix domain-containing protein	Antitoxin
BVG90_RS21555	4505915..4506190	+	276	WP_033636570.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BVG90_RS21560	4506202..4507113	-	912	WP_033639075.1	LysR family transcriptional regulator	-
BVG90_RS21565	4507235..4507861	+	627	WP_033639074.1	LysE family translocator	-
BVG90_RS21570	4507915..4509162	-	1248	WP_028127797.1	MFS transporter	-
BVG90_RS21575	4509380..4510372	+	993	WP_089185153.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10578.32 Da
• Isoelectric Point: 10.3377

>T70898 WP_033636570.1 NZ_CP018927:4505915-4506190 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T70898 NZ_CP018927:4505915-4506190 [Serratia marcescens]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9682.01 Da
• Isoelectric Point: 4.5317

>AT70898 WP_033639076.1 NZ_CP018927:4505655-4505915 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Nucleotide

• Length: 261 bp

>AT70898 NZ_CP018927:4505655-4505915 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAGCAAGCCCTCGCTGCCTGGCTTGAGCAAGAGGAAGAACGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D971