Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3868322..3869052 Replicon chromosome
Accession NZ_CP018927
Organism Serratia marcescens strain UMH8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BVG90_RS18555 Protein ID WP_089185072.1
Coordinates 3868322..3868633 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BVG90_RS18560 Protein ID WP_015379178.1
Coordinates 3868630..3869052 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG90_RS18525 3863635..3864360 + 726 WP_089185070.1 LPS export ABC transporter ATP-binding protein -
BVG90_RS18530 3864413..3865846 + 1434 WP_089185071.1 RNA polymerase factor sigma-54 -
BVG90_RS18535 3865870..3866157 + 288 WP_004937038.1 ribosome hibernation promoting factor -
BVG90_RS18540 3866313..3866774 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
BVG90_RS18545 3866904..3867758 + 855 WP_015379177.1 RNase adapter RapZ -
BVG90_RS18550 3867755..3868027 + 273 WP_004937034.1 PTS phosphocarrier protein NPr -
BVG90_RS18555 3868322..3868633 + 312 WP_089185072.1 type II toxin-antitoxin system HigB family toxin Toxin
BVG90_RS18560 3868630..3869052 + 423 WP_015379178.1 helix-turn-helix domain-containing protein Antitoxin
BVG90_RS18565 3869056..3870972 - 1917 WP_048797184.1 BglG family transcription antiterminator -
BVG90_RS18570 3871024..3872238 - 1215 WP_089185073.1 lactonase family protein -
BVG90_RS18575 3872515..3873255 - 741 WP_047573565.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12303.16 Da        Isoelectric Point: 10.0957

>T70897 WP_089185072.1 NZ_CP018927:3868322-3868633 [Serratia marcescens]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWLIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T70897 NZ_CP018927:3868322-3868633 [Serratia marcescens]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAGCAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCATTGCGACGGGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGCTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15784.13 Da        Isoelectric Point: 5.2139

>AT70897 WP_015379178.1 NZ_CP018927:3868630-3869052 [Serratia marcescens]
MITDAIKAADALLRAVPLLQGSRAQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT70897 NZ_CP018927:3868630-3869052 [Serratia marcescens]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTGCCCTTGTTGCAGGGCAGCCGCGCTCAGCAAGA
CTATCGGGAAGCGCTTGAATTGGTGGAATACCTGCTGGAAAACGACGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AGATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAGTTACCACAGGGGGTAGCC
GCGCTTCGCGTCCTTATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTTAA
CCAAATCCTGAACGGTAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAGCGTTTCAATCTGCCCCCGGCCC
TGTTCCTGCCGGAAGCGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References