Detailed information of TA system TA070894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3079226..3079882
• Replicon: chromosome
• Accession: NZ_CP018927
• Organism: Serratia marcescens strain UMH8

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A379YUY4
• Locus tag: BVG90_RS14735
• Protein ID: WP_033639649.1
• Coordinates: 3079226..3079615 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: BVG90_RS14740
• Protein ID: WP_004941563.1
• Coordinates: 3079619..3079882 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG90_RS14720	3075694..3077124	+	1431	WP_060445283.1	multidrug transporter subunit MdtD	-
BVG90_RS14725	3077121..3078503	+	1383	WP_016926705.1	two-component system sensor histidine kinase BaeS	-
BVG90_RS14730	3078503..3079219	+	717	WP_004941568.1	two-component system response regulator BaeR	-
BVG90_RS14735	3079226..3079615	-	390	WP_033639649.1	type II toxin-antitoxin system VapC family toxin	Toxin
BVG90_RS14740	3079619..3079882	-	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BVG90_RS14745	3080221..3080559	+	339	WP_016926703.1	YegP family protein	-
BVG90_RS14750	3080738..3082090	+	1353	WP_089184897.1	tRNA 5-hydroxyuridine modification protein YegQ	-
BVG90_RS14755	3082558..3083463	+	906	WP_016926701.1	lipid kinase YegS	-
BVG90_RS14760	3083632..3084846	+	1215	WP_089184898.1	D-galactonate dehydratase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14324.57 Da
• Isoelectric Point: 7.8794

>T70894 WP_033639649.1 NZ_CP018927:c3079615-3079226 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RATMERKGKIMGAIDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T70894 NZ_CP018927:c3079615-3079226 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT70894 WP_004941563.1 NZ_CP018927:c3079882-3079619 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT70894 NZ_CP018927:c3079882-3079619 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A379YUY4