Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 887705..888252 Replicon chromosome
Accession NZ_CP018927
Organism Serratia marcescens strain UMH8

Toxin (Protein)


Gene name ccdB Uniprot ID A0A380ADA6
Locus tag BVG90_RS04335 Protein ID WP_025302144.1
Coordinates 887944..888252 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3SUU9
Locus tag BVG90_RS04330 Protein ID WP_033633717.1
Coordinates 887705..887941 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG90_RS04315 884191..885726 + 1536 WP_016928459.1 glutathione ABC transporter substrate-binding protein GsiB -
BVG90_RS04320 885779..886699 + 921 WP_016928458.1 glutathione ABC transporter permease GsiC -
BVG90_RS04325 886709..887617 + 909 WP_197738900.1 glutathione ABC transporter permease GsiD -
BVG90_RS04330 887705..887941 + 237 WP_033633717.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
BVG90_RS04335 887944..888252 + 309 WP_025302144.1 CcdB family protein Toxin
BVG90_RS04340 888289..889131 - 843 WP_015377214.1 S-formylglutathione hydrolase -
BVG90_RS04345 889146..890270 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
BVG90_RS04350 890300..891220 - 921 WP_079449477.1 LysR family transcriptional regulator -
BVG90_RS04355 891326..892483 + 1158 WP_033640883.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11504.32 Da        Isoelectric Point: 5.0196

>T70885 WP_025302144.1 NZ_CP018927:887944-888252 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T70885 NZ_CP018927:887944-888252 [Serratia marcescens]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAATGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCCATCGATTTTCTGATTGATGGTTTTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8994.07 Da        Isoelectric Point: 5.0807

>AT70885 WP_033633717.1 NZ_CP018927:887705-887941 [Serratia marcescens]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT70885 NZ_CP018927:887705-887941 [Serratia marcescens]
ATGGCAAATAACAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTCCGTGTCAGGGACATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGTGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380ADA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SUU9

References