Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 951531..952141 Replicon chromosome
Accession NZ_CP018845
Organism Herbaspirillum robiniae strain AA6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BUQ72_RS04165 Protein ID WP_079214920.1
Coordinates 951531..951794 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BUQ72_RS04170 Protein ID WP_079219075.1
Coordinates 951815..952141 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUQ72_RS04145 947015..948088 - 1074 WP_079219074.1 MSMEG_0568 family radical SAM protein -
BUQ72_RS04150 948054..949142 - 1089 WP_079214918.1 Nit6803 family nitriliase -
BUQ72_RS04155 949161..949643 - 483 WP_006463016.1 MSMEG_0572 family nitrogen starvation response protein -
BUQ72_RS04160 950081..951475 + 1395 WP_079214919.1 PLP-dependent aminotransferase family protein -
BUQ72_RS04165 951531..951794 + 264 WP_079214920.1 type II toxin-antitoxin system HicA family toxin Toxin
BUQ72_RS04170 951815..952141 + 327 WP_079219075.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BUQ72_RS04175 952164..953093 - 930 WP_079214921.1 AraC family transcriptional regulator -
BUQ72_RS04180 953220..953963 + 744 WP_079214922.1 SDR family oxidoreductase -
BUQ72_RS04185 953980..954702 - 723 WP_079214923.1 alpha/beta fold hydrolase -
BUQ72_RS04190 954849..956240 + 1392 WP_079214924.1 PLP-dependent aminotransferase family protein -
BUQ72_RS04195 956244..957029 - 786 WP_122984461.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9697.11 Da        Isoelectric Point: 10.3535

>T70692 WP_079214920.1 NZ_CP018845:951531-951794 [Herbaspirillum robiniae]
MKSAHQKTLAAIFGNPVPTSLEWRKIEALFEALGAQIVEGNGSRVRFVLNGGIGTFHRPHPTKEAKPYQVRDARLFLQNA
GITPEWE

Download         Length: 264 bp

>T70692 NZ_CP018845:951531-951794 [Herbaspirillum robiniae]
ATGAAAAGCGCTCACCAAAAAACGCTGGCCGCCATCTTCGGGAATCCGGTTCCGACCTCATTGGAGTGGCGCAAGATAGA
AGCCCTGTTCGAGGCGCTCGGGGCACAGATTGTCGAAGGCAATGGTTCGCGTGTGAGATTTGTCCTCAACGGCGGCATCG
GCACCTTCCACCGGCCCCATCCGACCAAGGAGGCCAAGCCTTATCAGGTGCGCGACGCGCGATTGTTTTTGCAGAACGCC
GGCATCACGCCGGAATGGGAATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11885.34 Da        Isoelectric Point: 5.1404

>AT70692 WP_079219075.1 NZ_CP018845:951815-952141 [Herbaspirillum robiniae]
MGTMTYKGYAARIEYSDEDECFVGHIAGIRDVVGFHGDSVAALKAAFEEAVDDYLDTCAKLDKEPQRPYSGKFMLRVSPE
IHAHAATMAEARGLSLNAWAAEALSHYR

Download         Length: 327 bp

>AT70692 NZ_CP018845:951815-952141 [Herbaspirillum robiniae]
ATGGGAACGATGACCTACAAGGGCTACGCGGCCCGCATCGAATACAGTGATGAGGACGAATGCTTTGTCGGCCATATCGC
CGGCATTCGTGATGTGGTGGGCTTTCACGGCGACTCTGTGGCGGCGCTGAAAGCGGCCTTCGAGGAGGCGGTAGACGATT
ATCTCGACACCTGCGCGAAGCTCGACAAGGAGCCTCAGCGGCCTTATTCGGGCAAGTTCATGCTCCGGGTGTCGCCTGAG
ATACATGCGCACGCCGCCACCATGGCCGAGGCGCGCGGGCTGAGCCTGAATGCCTGGGCGGCCGAGGCCTTGTCCCACTA
TCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References