Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 4325139..4325904 Replicon chromosome
Accession NZ_CP018671
Organism Klebsiella pneumoniae strain CAV1042

Toxin (Protein)


Gene name ypjF Uniprot ID A0A443W6R0
Locus tag AGE78_RS24460 Protein ID WP_032729493.1
Coordinates 4325536..4325904 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A330G4J1
Locus tag AGE78_RS24455 Protein ID WP_032729492.1
Coordinates 4325139..4325495 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGE78_RS24410 4320301..4321185 + 885 WP_032729486.1 50S ribosome-binding GTPase -
AGE78_RS24420 4321635..4322363 + 729 WP_032729489.1 WYL domain-containing protein -
AGE78_RS31765 4322585..4322863 + 279 WP_176694317.1 hypothetical protein -
AGE78_RS24430 4322925..4323185 + 261 WP_032730962.1 hypothetical protein -
AGE78_RS24435 4323198..4323509 + 312 WP_032729490.1 hypothetical protein -
AGE78_RS24440 4323592..4323948 + 357 WP_032729491.1 hypothetical protein -
AGE78_RS24445 4324145..4324603 + 459 WP_050597274.1 antirestriction protein -
AGE78_RS24450 4324631..4325110 + 480 WP_032730964.1 DNA repair protein RadC -
AGE78_RS24455 4325139..4325495 + 357 WP_032729492.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AGE78_RS24460 4325536..4325904 + 369 WP_032729493.1 TA system toxin CbtA family protein Toxin
AGE78_RS24465 4325901..4326230 + 330 WP_050597275.1 hypothetical protein -
AGE78_RS24470 4326330..4326434 + 105 Protein_4123 restriction endonuclease subunit M -
AGE78_RS24475 4327143..4327427 + 285 WP_004183235.1 hypothetical protein -
AGE78_RS24480 4327896..4328435 - 540 WP_032436961.1 hypothetical protein -
AGE78_RS24485 4328817..4329218 + 402 WP_002892366.1 hydroxyisourate hydrolase -
AGE78_RS24490 4329297..4329467 - 171 WP_002892370.1 hypothetical protein -
AGE78_RS31770 4329792..4329932 + 141 WP_004142684.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13412.45 Da        Isoelectric Point: 9.1775

>T70177 WP_032729493.1 NZ_CP018671:4325536-4325904 [Klebsiella pneumoniae]
MRTVPAPPSRAAQTCPSPITVWQSLLTYLLAQHYGLTLNDTAFSDDAVIQAHIDNGMSLADVLNAMVEKFELVRIDRRGF
TGQAQSPLVTVIDILRARRACGLMTRAGYREVTRAIQGSKQP

Download         Length: 369 bp

>T70177 NZ_CP018671:4325536-4325904 [Klebsiella pneumoniae]
ATGCGAACAGTACCCGCACCACCGTCAAGGGCGGCCCAAACATGCCCGTCTCCCATAACTGTCTGGCAATCCTTGCTCAC
CTACCTGCTGGCGCAGCACTACGGCCTGACGCTCAACGATACCGCGTTCAGCGACGATGCCGTGATACAGGCACACATCG
ATAACGGTATGTCCCTCGCGGATGTGCTGAATGCCATGGTGGAAAAGTTTGAGCTGGTGCGCATTGACCGCCGGGGCTTC
ACCGGACAGGCGCAATCGCCCCTTGTGACCGTCATCGACATCCTGCGCGCCCGCCGGGCCTGTGGCCTGATGACGCGAGC
CGGCTACCGGGAGGTCACACGTGCCATTCAGGGAAGCAAGCAACCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13508.27 Da        Isoelectric Point: 6.9037

>AT70177 WP_032729492.1 NZ_CP018671:4325139-4325495 [Klebsiella pneumoniae]
MPSPHNVPAWGLKRNVTPQFGARLVQERERLHFLADRADISGIFSDAQRHDLENAFPQFIKHLELMLLSGELNPRHQHCV
TLYCHGLTCEADSLGSYGYVYISIYPTSETPRYNAPHF

Download         Length: 357 bp

>AT70177 NZ_CP018671:4325139-4325495 [Klebsiella pneumoniae]
ATGCCATCACCCCATAATGTTCCCGCCTGGGGGCTGAAACGCAACGTCACGCCGCAGTTTGGCGCCCGTCTGGTACAGGA
GAGGGAACGACTGCATTTTCTGGCCGACCGGGCAGACATCAGCGGAATTTTCAGCGACGCACAGCGCCATGATTTGGAGA
ATGCTTTTCCGCAGTTCATCAAGCATTTGGAATTGATGCTGCTTTCCGGTGAGCTCAATCCGCGTCATCAGCACTGTGTC
ACACTGTATTGCCATGGCCTGACCTGCGAAGCAGACAGCCTCGGCTCATACGGCTACGTCTACATTTCGATTTATCCGAC
ATCTGAAACGCCCAGGTATAACGCCCCGCATTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A443W6R0

Antitoxin

Source ID Structure
AlphaFold DB A0A330G4J1

References