Detailed information of TA system TA070144

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 68020..68545
• Replicon: plasmid pSE81-1706
• Accession: NZ_CP018656
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain 81-1706

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: BTN76_RS24425
• Protein ID: WP_001159863.1
• Coordinates: 68020..68325 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: BTN76_RS24430
• Protein ID: WP_000813641.1
• Coordinates: 68327..68545 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTN76_RS24390	63399..63959	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
BTN76_RS25850	64115..64402	+	288	WP_071530243.1	hypothetical protein	-
BTN76_RS24395	64679..65164	-	486	WP_058107032.1	hypothetical protein	-
BTN76_RS24400	65158..65667	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
BTN76_RS24405	65671..66384	-	714	WP_000545756.1	EAL domain-containing protein	-
BTN76_RS24410	66393..67175	-	783	WP_000082169.1	site-specific integrase	-
BTN76_RS24415	67210..67731	-	522	WP_099828416.1	cytoplasmic protein	-
BTN76_RS24420	67728..68018	-	291	WP_001266176.1	hypothetical protein	-
BTN76_RS24425	68020..68325	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
BTN76_RS24430	68327..68545	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
BTN76_RS24435	69221..69742	+	522	WP_080199465.1	hypothetical protein	-
BTN76_RS25855	69786..70214	-	429	Protein_70	hypothetical protein	-
BTN76_RS24445	70226..70521	+	296	Protein_71	cytoplasmic protein	-
BTN76_RS24450	71015..72004	+	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
BTN76_RS24455	72293..72454	-	162	WP_015059604.1	hypothetical protein	-
BTN76_RS24460	72507..72893	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..244210	244210

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin GhoT/OrtT (4-57)

Antitoxin

• Endoribonuclease antitoxin GhoS (5-94)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T70144 WP_001159863.1 NZ_CP018656:c68325-68020 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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Nucleotide

• Length: 306 bp

>T70144 NZ_CP018656:c68325-68020 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT70144 WP_000813641.1 NZ_CP018656:c68545-68327 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT70144 NZ_CP018656:c68545-68327 [Salmonella enterica subsp. enterica serovar Enteritidis]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6