Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4083497..4084116 Replicon chromosome
Accession NZ_CP018364
Organism Klebsiella pneumoniae strain Kp_Goe_62629

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag BB790_RS21610 Protein ID WP_002892050.1
Coordinates 4083898..4084116 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag BB790_RS21605 Protein ID WP_002892066.1
Coordinates 4083497..4083871 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB790_RS21595 4078649..4079842 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BB790_RS21600 4079865..4083011 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
BB790_RS21605 4083497..4083871 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
BB790_RS21610 4083898..4084116 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
BB790_RS21615 4084275..4084841 + 567 WP_002892030.1 maltose O-acetyltransferase -
BB790_RS32400 4084813..4084953 - 141 WP_004147370.1 hypothetical protein -
BB790_RS21625 4084974..4085444 + 471 WP_002892026.1 YlaC family protein -
BB790_RS21630 4085419..4086870 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
BB790_RS21635 4086971..4087669 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
BB790_RS21640 4087666..4087806 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
BB790_RS21645 4087806..4088069 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T69862 WP_002892050.1 NZ_CP018364:4083898-4084116 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T69862 NZ_CP018364:4083898-4084116 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT69862 WP_002892066.1 NZ_CP018364:4083497-4083871 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT69862 NZ_CP018364:4083497-4083871 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References