Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2388923..2389452 Replicon chromosome
Accession NZ_CP018300
Organism Mycobacterium tuberculosis strain I0002353-6

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag BOM19_RS11575 Protein ID WP_003411124.1
Coordinates 2388923..2389240 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag BOM19_RS11580 Protein ID WP_003411127.1
Coordinates 2389237..2389452 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOM19_RS11545 2384118..2385194 + 1077 WP_003411110.1 hypothetical protein -
BOM19_RS11550 2385191..2385472 + 282 WP_003411112.1 hypothetical protein -
BOM19_RS11555 2385508..2386581 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
BOM19_RS11560 2386586..2387116 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
BOM19_RS11565 2387164..2388510 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
BOM19_RS11575 2388923..2389240 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BOM19_RS11580 2389237..2389452 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
BOM19_RS11585 2389707..2390765 + 1059 WP_003411129.1 hypothetical protein -
BOM19_RS11590 2390895..2391251 - 357 WP_003411130.1 hypothetical protein -
BOM19_RS11595 2391346..2392128 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
BOM19_RS11600 2392396..2392686 - 291 WP_003900476.1 YggT family protein -
BOM19_RS11605 2392848..2393504 - 657 WP_003411133.1 cell division protein SepF -
BOM19_RS11610 2393570..2394346 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T69344 WP_003411124.1 NZ_CP018300:c2389240-2388923 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T69344 NZ_CP018300:c2389240-2388923 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT69344 WP_003411127.1 NZ_CP018300:c2389452-2389237 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT69344 NZ_CP018300:c2389452-2389237 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References