Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1198722..1199200 Replicon chromosome
Accession NZ_CP018247
Organism Escherichia coli strain 7784

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag BFL18_RS06130 Protein ID WP_001303876.1
Coordinates 1198722..1199009 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag BFL18_RS06135 Protein ID WP_000536233.1
Coordinates 1199009..1199200 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL18_RS06080 1193871..1196342 - 2472 WP_000034474.1 exonuclease -
BFL18_RS06085 1196436..1196627 - 192 WP_001098307.1 DUF1482 family protein -
BFL18_RS06090 1196624..1196812 - 189 WP_000413705.1 cell division inhibition protein DicB -
BFL18_RS06100 1197386..1197571 + 186 WP_001133046.1 hypothetical protein -
BFL18_RS06105 1197758..1198147 - 390 WP_000394511.1 hypothetical protein -
BFL18_RS06115 1198289..1198444 - 156 WP_000379575.1 DUF1391 family protein -
BFL18_RS06130 1198722..1199009 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFL18_RS06135 1199009..1199200 - 192 WP_000536233.1 hypothetical protein Antitoxin
BFL18_RS06140 1199228..1199629 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
BFL18_RS06145 1199738..1200010 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
BFL18_RS06150 1199994..1200419 + 426 WP_000693855.1 Rha family transcriptional regulator -
BFL18_RS06155 1200626..1201081 - 456 WP_000273724.1 hypothetical protein -
BFL18_RS06160 1201160..1202269 + 1110 WP_021499850.1 putative primosomal protein I -
BFL18_RS06165 1202276..1203022 + 747 WP_000788751.1 ATP-binding protein -
BFL18_RS06170 1203044..1203814 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T69174 WP_001303876.1 NZ_CP018247:c1199009-1198722 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T69174 NZ_CP018247:c1199009-1198722 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT69174 WP_000536233.1 NZ_CP018247:c1199200-1199009 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT69174 NZ_CP018247:c1199200-1199009 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References