Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2119443..2120277 Replicon chromosome
Accession NZ_CP017844
Organism Escherichia coli strain FMU073332

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag BLJ80_RS11530 Protein ID WP_140159973.1
Coordinates 2119443..2119811 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag BLJ80_RS11535 Protein ID WP_001285580.1
Coordinates 2119909..2120277 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLJ80_RS11505 2114570..2115718 - 1149 WP_000905925.1 capsule polysaccharide transporter -
BLJ80_RS11510 2115790..2116773 - 984 WP_032328464.1 KpsF/GutQ family sugar-phosphate isomerase -
BLJ80_RS11515 2117584..2117754 - 171 Protein_1997 IS110 family transposase -
BLJ80_RS11520 2118097..2118939 - 843 WP_001280493.1 DUF4942 domain-containing protein -
BLJ80_RS29240 2119024..2119221 - 198 WP_023563519.1 DUF957 domain-containing protein -
BLJ80_RS29245 2119297..2119446 - 150 Protein_2000 hypothetical protein -
BLJ80_RS11530 2119443..2119811 - 369 WP_140159973.1 TA system toxin CbtA family protein Toxin
BLJ80_RS11535 2119909..2120277 - 369 WP_001285580.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BLJ80_RS11540 2120356..2120577 - 222 WP_000691818.1 DUF987 domain-containing protein -
BLJ80_RS11550 2120714..2120893 - 180 WP_001398324.1 hypothetical protein -
BLJ80_RS11560 2120935..2121632 + 698 Protein_2005 IS1 family transposase -
BLJ80_RS11565 2122441..2122665 + 225 WP_001395295.1 transposase -
BLJ80_RS11570 2122667..2122804 - 138 Protein_2007 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-109)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13616.51 Da        Isoelectric Point: 9.1652

>T68199 WP_140159973.1 NZ_CP017844:c2119811-2119443 [Escherichia coli]
ITQHTRTGGIARPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVSFLVEKYALVRTDQPGFSAC
TRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 369 bp

>T68199 NZ_CP017844:c2119811-2119443 [Escherichia coli]
ATTACCCAACACACACGTACGGGAGGCATCGCGCGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTCCCGGTTGCT
GGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTGAAGCTGGCA
TTTCACTGTGTGATGCGGTGAGCTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTCAGCGCCTGT
ACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGACAACTACAG
AACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13670.43 Da        Isoelectric Point: 6.9462

>AT68199 WP_001285580.1 NZ_CP017844:c2120277-2119909 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADSYHLNQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT68199 NZ_CP017844:c2120277-2119909 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGAACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References