Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 803662..804496 Replicon chromosome
Accession NZ_CP017844
Organism Escherichia coli strain FMU073332

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag BLJ80_RS04435 Protein ID WP_000854727.1
Coordinates 804119..804496 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag BLJ80_RS04430 Protein ID WP_024183700.1
Coordinates 803662..804030 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLJ80_RS04390 799388..800272 + 885 WP_000010388.1 50S ribosome-binding GTPase -
BLJ80_RS29750 800391..800651 + 261 WP_172902803.1 hypothetical protein -
BLJ80_RS29755 800691..801068 + 378 WP_172902802.1 hypothetical protein -
BLJ80_RS04400 801074..801307 + 234 WP_001278281.1 DUF905 family protein -
BLJ80_RS04410 801406..802224 + 819 WP_001234693.1 DUF945 domain-containing protein -
BLJ80_RS04415 802316..802801 + 486 WP_000206660.1 antirestriction protein -
BLJ80_RS04420 802816..803292 + 477 WP_032328266.1 RadC family protein -
BLJ80_RS04425 803361..803582 + 222 WP_000692295.1 DUF987 domain-containing protein -
BLJ80_RS04430 803662..804030 + 369 WP_024183700.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BLJ80_RS04435 804119..804496 + 378 WP_000854727.1 TA system toxin CbtA family protein Toxin
BLJ80_RS04440 804493..804981 + 489 WP_032328344.1 hypothetical protein -
BLJ80_RS04445 804993..805190 + 198 WP_000839291.1 DUF957 domain-containing protein -
BLJ80_RS04450 805275..806141 + 867 WP_001280426.1 DUF4942 domain-containing protein -
BLJ80_RS04455 806213..806476 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
BLJ80_RS04460 806473..806799 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
BLJ80_RS04465 807245..808489 + 1245 WP_001219071.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vipB/tssC / vipA/tssB 759168..883463 124295


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14345.39 Da        Isoelectric Point: 9.2442

>T68193 WP_000854727.1 NZ_CP017844:804119-804496 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKR

Download         Length: 378 bp

>T68193 NZ_CP017844:804119-804496 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTGTC
CCGCCTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13617.41 Da        Isoelectric Point: 7.7474

>AT68193 WP_024183700.1 NZ_CP017844:803662-804030 [Escherichia coli]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp

>AT68193 NZ_CP017844:803662-804030 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGTACCGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAATTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References