Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4664038..4664717 Replicon chromosome
Accession NZ_CP017777
Organism Klebsiella pneumoniae strain KP36M

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag BK002_RS22245 Protein ID WP_020324801.1
Coordinates 4664038..4664379 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag BK002_RS22250 Protein ID WP_020324792.1
Coordinates 4664400..4664717 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK002_RS22225 4660339..4662180 + 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
BK002_RS22230 4662280..4662786 - 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
BK002_RS22240 4663089..4663922 - 834 WP_020324805.1 DUF4942 domain-containing protein -
BK002_RS22245 4664038..4664379 - 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
BK002_RS22250 4664400..4664717 - 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BK002_RS22255 4664730..4664957 - 228 WP_020324796.1 DUF987 domain-containing protein -
BK002_RS22260 4664966..4665442 - 477 WP_020324797.1 RadC family protein -
BK002_RS22265 4665458..4665916 - 459 WP_020324813.1 antirestriction protein -
BK002_RS22270 4666019..4666258 - 240 WP_020324820.1 DUF905 domain-containing protein -
BK002_RS22275 4666351..4669503 - 3153 WP_022631414.1 AIDA repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimG / fimF / fimD / fimA 4663089..4710592 47503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T68147 WP_020324801.1 NZ_CP017777:c4664379-4664038 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T68147 NZ_CP017777:c4664379-4664038 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT68147 WP_020324792.1 NZ_CP017777:c4664717-4664400 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT68147 NZ_CP017777:c4664717-4664400 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References