Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 58184..58709 Replicon plasmid pCFSAN017963_01
Accession NZ_CP017721
Organism Salmonella enterica subsp. enterica serovar Minnesota strain CFSAN017963

Toxin (Protein)


Gene name ccdB Uniprot ID A0A5V6NLW6
Locus tag GX95_RS24340 Protein ID WP_071624921.1
Coordinates 58404..58709 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A5V7P8D1
Locus tag GX95_RS24335 Protein ID WP_071624922.1
Coordinates 58184..58402 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GX95_RS24315 54893..55141 - 249 WP_071624923.1 tail fiber assembly protein -
GX95_RS24320 55309..55917 + 609 WP_088137190.1 IS66 family insertion sequence hypothetical protein -
GX95_RS24325 55914..56261 + 348 WP_088137191.1 IS66 family insertion sequence element accessory protein TnpB -
GX95_RS24330 56281..57836 + 1556 Protein_41 IS66 family transposase -
GX95_RS24335 58184..58402 + 219 WP_071624922.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
GX95_RS24340 58404..58709 + 306 WP_071624921.1 type II toxin-antitoxin system toxin CcdB Toxin
GX95_RS24345 58711..59001 + 291 WP_088137192.1 cytoplasmic protein -
GX95_RS24350 58998..59470 + 473 Protein_45 cytoplasmic protein -
GX95_RS24355 59505..60287 + 783 WP_071624929.1 site-specific integrase -
GX95_RS24360 60520..61383 - 864 WP_060634124.1 RepB family plasmid replication initiator protein -
GX95_RS25935 61671..61790 - 120 Protein_48 hypothetical protein -
GX95_RS24365 61886..62576 + 691 Protein_49 hypothetical protein -
GX95_RS24370 62621..62846 + 226 Protein_50 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..280421 280421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T68077 WP_071624921.1 NZ_CP017721:58404-58709 [Salmonella enterica subsp. enterica serovar Minnesota]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T68077 NZ_CP017721:58404-58709 [Salmonella enterica subsp. enterica serovar Minnesota]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT68077 WP_071624922.1 NZ_CP017721:58184-58402 [Salmonella enterica subsp. enterica serovar Minnesota]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT68077 NZ_CP017721:58184-58402 [Salmonella enterica subsp. enterica serovar Minnesota]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5V6NLW6

Antitoxin

Source ID Structure
AlphaFold DB A0A5V7P8D1

References