Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2467996..2468180 Replicon chromosome
Accession NZ_CP017682
Organism Staphylococcus aureus strain CFSAN007850

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag AB526_RS12830 Protein ID WP_000482652.1
Coordinates 2468073..2468180 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2467996..2468056 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB526_RS12805 2463451..2463618 - 168 Protein_2373 hypothetical protein -
AB526_RS12815 2463849..2465582 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
AB526_RS12820 2465607..2467370 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2467996..2468056 + 61 - - Antitoxin
AB526_RS12830 2468073..2468180 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
AB526_RS12835 2468314..2468700 - 387 WP_000779360.1 flippase GtxA -
AB526_RS12840 2468968..2470110 + 1143 WP_001176863.1 glycerate kinase -
AB526_RS12845 2470170..2470829 + 660 WP_000831298.1 membrane protein -
AB526_RS12850 2471011..2472222 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
AB526_RS12855 2472345..2472818 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T68029 WP_000482652.1 NZ_CP017682:c2468180-2468073 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T68029 NZ_CP017682:c2468180-2468073 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT68029 NZ_CP017682:2467996-2468056 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References