Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2078001..2078530 Replicon chromosome
Accession NZ_CP017680
Organism Staphylococcus aureus strain CFSAN007851

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag AB454_RS10710 Protein ID WP_000621175.1
Coordinates 2078001..2078363 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag AB454_RS10715 Protein ID WP_000948331.1
Coordinates 2078360..2078530 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB454_RS10685 2074979..2075749 - 771 WP_001041108.1 RNA polymerase sigma factor SigB -
AB454_RS10690 2075724..2076203 - 480 WP_001190830.1 anti-sigma B factor RsbW -
AB454_RS10695 2076205..2076531 - 327 WP_001052491.1 anti-sigma factor antagonist -
AB454_RS10700 2076650..2077651 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
AB454_RS10710 2078001..2078363 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AB454_RS10715 2078360..2078530 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
AB454_RS10720 2078615..2079763 - 1149 WP_001281154.1 alanine racemase -
AB454_RS10725 2079829..2080188 - 360 WP_000581197.1 holo-ACP synthase -
AB454_RS10730 2080192..2080683 - 492 WP_001205912.1 PH domain-containing protein -
AB454_RS10735 2080670..2082253 - 1584 WP_099143845.1 PH domain-containing protein -
AB454_RS10740 2082246..2082725 - 480 WP_001287078.1 hypothetical protein -
AB454_RS10745 2082934..2083494 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T68006 WP_000621175.1 NZ_CP017680:c2078363-2078001 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T68006 NZ_CP017680:c2078363-2078001 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT68006 WP_000948331.1 NZ_CP017680:c2078530-2078360 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT68006 NZ_CP017680:c2078530-2078360 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References