Detailed information of TA system TA067906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 53749..54407
• Replicon: plasmid pKAB07
• Accession: NZ_CP017655
• Organism: Acinetobacter baumannii strain KAB07

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KAB07_RS19445
• Protein ID: WP_000312250.1
• Coordinates: 54048..54407 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KAB07_RS19440
• Protein ID: WP_001096429.1
• Coordinates: 53749..54048 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAB07_RS19395	48782..49039	+	258	WP_000834292.1	hypothetical protein	-
KAB07_RS19400	49044..49616	+	573	WP_000429351.1	hypothetical protein	-
KAB07_RS19405	49592..49771	+	180	WP_002081921.1	hypothetical protein	-
KAB07_RS19410	49788..50417	+	630	WP_002081923.1	hypothetical protein	-
KAB07_RS19415	50457..50966	+	510	WP_001043199.1	hypothetical protein	-
KAB07_RS19420	51047..51601	+	555	WP_000790085.1	hypothetical protein	-
KAB07_RS19425	51651..52187	+	537	WP_000731981.1	hypothetical protein	-
KAB07_RS19430	52810..53292	+	483	WP_001052677.1	hypothetical protein	-
KAB07_RS19435	53385..53648	-	264	WP_000110863.1	hypothetical protein	-
KAB07_RS19440	53749..54048	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
KAB07_RS19445	54048..54407	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAB07_RS19450	54608..55174	+	567	WP_041171756.1	hypothetical protein	-
KAB07_RS19455	55223..55405	+	183	WP_000373385.1	hypothetical protein	-
KAB07_RS19460	55472..56170	+	699	WP_000873190.1	hypothetical protein	-
KAB07_RS19465	56309..56692	+	384	WP_000654349.1	hypothetical protein	-
KAB07_RS19470	56759..57517	+	759	WP_001053129.1	hypothetical protein	-
KAB07_RS19475	58585..58899	+	315	WP_000708714.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..72073	72073

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T67906 WP_000312250.1 NZ_CP017655:c54407-54048 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T67906 NZ_CP017655:c54407-54048 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT67906 WP_001096429.1 NZ_CP017655:c54048-53749 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT67906 NZ_CP017655:c54048-53749 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA