Detailed information of TA system TA067894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 44422..45080
• Replicon: plasmid unnamed
• Accession: NZ_CP017645
• Organism: Acinetobacter baumannii strain KAB02

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KAB02_RS19485
• Protein ID: WP_000312250.1
• Coordinates: 44422..44781 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KAB02_RS19490
• Protein ID: WP_001096429.1
• Coordinates: 44781..45080 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAB02_RS19455	39928..40242	-	315	WP_000708714.1	hypothetical protein	-
KAB02_RS19460	41312..42070	-	759	WP_001053129.1	hypothetical protein	-
KAB02_RS19465	42137..42520	-	384	WP_000654349.1	hypothetical protein	-
KAB02_RS19470	42659..43357	-	699	WP_000873190.1	hypothetical protein	-
KAB02_RS19475	43424..43606	-	183	WP_000373385.1	hypothetical protein	-
KAB02_RS19480	43655..44221	-	567	WP_041171756.1	hypothetical protein	-
KAB02_RS19485	44422..44781	+	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAB02_RS19490	44781..45080	+	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
KAB02_RS19495	45181..45444	+	264	WP_000110863.1	hypothetical protein	-
KAB02_RS19500	45537..46019	-	483	WP_001052677.1	hypothetical protein	-
KAB02_RS19505	46642..47178	-	537	WP_000731981.1	hypothetical protein	-
KAB02_RS19510	47228..47782	-	555	WP_000790085.1	hypothetical protein	-
KAB02_RS19515	47863..48372	-	510	WP_001043199.1	hypothetical protein	-
KAB02_RS19520	48412..49041	-	630	WP_002081923.1	hypothetical protein	-
KAB02_RS19525	49058..49237	-	180	WP_002081921.1	hypothetical protein	-
KAB02_RS19530	49213..49785	-	573	WP_000429351.1	hypothetical protein	-
KAB02_RS19535	49790..50047	-	258	WP_000834292.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..81227	81227

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T67894 WP_000312250.1 NZ_CP017645:44422-44781 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T67894 NZ_CP017645:44422-44781 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT67894 WP_001096429.1 NZ_CP017645:44781-45080 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT67894 NZ_CP017645:44781-45080 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA