Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2195165..2195709 Replicon chromosome
Accession NZ_CP017598
Organism Mycobacterium tuberculosis strain Beijing-like/1104

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag BJM04_RS10575 Protein ID WP_003409896.1
Coordinates 2195165..2195461 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag BJM04_RS10580 Protein ID WP_003409899.1
Coordinates 2195458..2195709 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM04_RS10520 2190198..2190548 - 351 WP_003409871.1 hypothetical protein -
BJM04_RS10525 2190559..2191461 - 903 WP_003899097.1 hypothetical protein -
BJM04_RS10530 2191482..2191673 - 192 WP_003409876.1 hypothetical protein -
BJM04_RS10535 2191674..2191970 - 297 WP_003409877.1 hypothetical protein -
BJM04_RS10540 2192210..2192425 + 216 WP_003409878.1 antitoxin -
BJM04_RS10545 2192422..2192733 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
BJM04_RS21810 2192707..2193228 - 522 WP_003904745.1 hypothetical protein -
BJM04_RS10555 2193203..2193580 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
BJM04_RS10560 2193622..2194071 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
BJM04_RS10565 2194068..2194613 + 546 WP_003409891.1 SecB-like chaperone -
BJM04_RS10570 2194502..2195116 - 615 WP_003901296.1 hypothetical protein -
BJM04_RS10575 2195165..2195461 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BJM04_RS10580 2195458..2195709 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BJM04_RS10585 2195696..2196190 + 495 WP_003899099.1 hypothetical protein -
BJM04_RS10590 2196350..2196757 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
BJM04_RS10595 2196761..2197033 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BJM04_RS10600 2197066..2198286 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
BJM04_RS10615 2199185..2199982 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T67770 WP_003409896.1 NZ_CP017598:c2195461-2195165 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T67770 NZ_CP017598:c2195461-2195165 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT67770 WP_003409899.1 NZ_CP017598:c2195709-2195458 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT67770 NZ_CP017598:c2195709-2195458 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References