Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3198077..3198764 Replicon chromosome
Accession NZ_CP017594
Organism Mycobacterium tuberculosis strain Beijing-like/36918

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag BJM00_RS15765 Protein ID WP_003414624.1
Coordinates 3198321..3198764 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag BJM00_RS15760 Protein ID WP_003414620.1
Coordinates 3198077..3198334 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM00_RS15740 3193397..3194251 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
BJM00_RS15745 3194307..3195470 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
BJM00_RS15750 3195487..3196701 - 1215 WP_003414610.1 zinc metalloprotease Rip -
BJM00_RS15755 3196709..3197950 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
BJM00_RS15760 3198077..3198334 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
BJM00_RS15765 3198321..3198764 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
BJM00_RS15770 3198844..3199506 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
BJM00_RS15775 3199602..3199793 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BJM00_RS15780 3200125..3201873 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
BJM00_RS15785 3201969..3202550 + 582 WP_003414644.1 fasciclin domain-containing protein -
BJM00_RS15790 3202650..3202916 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T67552 WP_003414624.1 NZ_CP017594:3198321-3198764 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T67552 NZ_CP017594:3198321-3198764 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT67552 WP_003414620.1 NZ_CP017594:3198077-3198334 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT67552 NZ_CP017594:3198077-3198334 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References