Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2876808..2877517 Replicon chromosome
Accession NZ_CP017593
Organism Mycobacterium tuberculosis strain Beijing-like/35049

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag BJL99_RS13990 Protein ID WP_003413164.1
Coordinates 2876808..2877221 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag BJL99_RS13995 Protein ID WP_003413167.1
Coordinates 2877260..2877517 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJL99_RS13955 2871861..2873066 - 1206 WP_003413027.1 chorismate synthase -
BJL99_RS13960 2873174..2873488 + 315 WP_009937839.1 hypothetical protein -
BJL99_RS13965 2873784..2874995 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
BJL99_RS13975 2875122..2875781 + 660 WP_003902296.1 hypothetical protein -
BJL99_RS13980 2875778..2876441 + 664 Protein_2644 hypothetical protein -
BJL99_RS21655 2876438..2876715 + 278 Protein_2645 type II toxin-antitoxin system VapB family antitoxin -
BJL99_RS13990 2876808..2877221 + 414 WP_003413164.1 PIN domain nuclease Toxin
BJL99_RS13995 2877260..2877517 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
BJL99_RS14000 2877514..2877891 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
BJL99_RS14005 2877907..2878281 - 375 WP_003413177.1 hypothetical protein -
BJL99_RS14010 2878381..2878776 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
BJL99_RS14015 2878773..2879018 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
BJL99_RS14025 2879429..2879848 - 420 WP_003413190.1 A24 family peptidase -
BJL99_RS14030 2879860..2880669 - 810 WP_003413193.1 shikimate dehydrogenase -
BJL99_RS14035 2880666..2881919 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
BJL99_RS14040 2881912..2882424 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T67481 WP_003413164.1 NZ_CP017593:2876808-2877221 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T67481 NZ_CP017593:2876808-2877221 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT67481 WP_003413167.1 NZ_CP017593:2877260-2877517 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT67481 NZ_CP017593:2877260-2877517 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References