Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2569771..2570441 Replicon chromosome
Accession NZ_CP017415
Organism Acidihalobacter yilgarnenesis strain F5

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D8IQ63
Locus tag BI364_RS12335 Protein ID WP_070079000.1
Coordinates 2569771..2570190 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D8ITK0
Locus tag BI364_RS12340 Protein ID WP_070080060.1
Coordinates 2570187..2570441 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI364_RS17975 2566000..2566299 + 300 WP_070080059.1 LysM peptidoglycan-binding domain-containing protein -
BI364_RS12315 2566480..2566926 - 447 WP_156782745.1 hypothetical protein -
BI364_RS12320 2567104..2567412 + 309 WP_070078997.1 hypothetical protein -
BI364_RS17980 2567475..2567624 + 150 WP_156782746.1 hypothetical protein -
BI364_RS12325 2567621..2568859 + 1239 WP_070078998.1 transposase -
BI364_RS12330 2569099..2569455 - 357 WP_207644991.1 hypothetical protein -
BI364_RS12335 2569771..2570190 - 420 WP_070079000.1 type II toxin-antitoxin system VapC family toxin Toxin
BI364_RS12340 2570187..2570441 - 255 WP_070080060.1 Arc family DNA-binding protein Antitoxin
BI364_RS12345 2570896..2572062 - 1167 WP_070079001.1 MFS transporter -
BI364_RS12350 2572204..2573595 - 1392 WP_070079002.1 hypothetical protein -
BI364_RS12355 2573727..2574704 - 978 WP_070079003.1 UDP-glucose 4-epimerase GalE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2567621..2568859 1238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15026.68 Da        Isoelectric Point: 5.1528

>T66505 WP_070079000.1 NZ_CP017415:c2570190-2569771 [Acidihalobacter yilgarnenesis]
MILLDTNVVSEPLRRDPEPRIIEWLDAQPLETLCLSAITVAELRMGVALLPSGKRRDGLKAHLEKQVLPLFVGRVLPFDM
SCTQAYAELMTKTKMAGIAIAAPDGFIAAIAAANSFVVATRDTGPFQAAGVEVLNPWVI

Download         Length: 420 bp

>T66505 NZ_CP017415:c2570190-2569771 [Acidihalobacter yilgarnenesis]
ATGATTCTGCTCGATACCAACGTGGTCTCAGAACCTCTGCGTCGTGATCCGGAACCACGAATCATAGAGTGGCTCGACGC
ACAGCCGCTGGAAACTCTCTGTCTTTCTGCCATCACGGTGGCAGAGTTGCGCATGGGTGTTGCGCTCCTCCCTTCGGGTA
AACGTCGGGATGGATTGAAAGCGCACCTGGAAAAGCAGGTCTTGCCCCTCTTCGTCGGGCGTGTGCTGCCCTTCGATATG
AGTTGCACGCAAGCTTATGCTGAGTTGATGACGAAGACAAAAATGGCGGGAATCGCCATTGCTGCACCTGACGGCTTTAT
CGCTGCTATCGCAGCAGCCAACAGTTTTGTCGTGGCCACGCGAGATACGGGCCCCTTTCAGGCAGCAGGGGTGGAAGTTC
TTAATCCTTGGGTTATTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9337.63 Da        Isoelectric Point: 7.0176

>AT66505 WP_070080060.1 NZ_CP017415:c2570441-2570187 [Acidihalobacter yilgarnenesis]
MSSITVRNVPEEVRRALRVRAAQHGRSAEAEIREILEQAVKPEGRVKLGSLLAGIGREARLSDSEFAIIEQVRDQTPAQI
LSFE

Download         Length: 255 bp

>AT66505 NZ_CP017415:c2570441-2570187 [Acidihalobacter yilgarnenesis]
ATGTCATCCATAACGGTTAGAAATGTGCCTGAAGAGGTGCGCCGCGCATTGCGCGTGCGGGCCGCCCAACATGGCCGAAG
CGCTGAGGCGGAAATTCGCGAGATCCTTGAGCAAGCCGTGAAGCCGGAAGGACGGGTGAAATTAGGCTCGTTACTGGCTG
GTATCGGGCGGGAGGCAAGACTGAGCGACTCGGAATTCGCCATTATCGAGCAGGTGCGTGATCAGACACCAGCACAGATC
TTGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8IQ63

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8ITK0

References