Detailed information of TA system TA066469

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4909015..4909598
• Replicon: chromosome
• Accession: NZ_CP017311
• Organism: Hydrogenophaga sp. PBC

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: Q5W_RS23355
• Protein ID: WP_035622005.1
• Coordinates: 4909344..4909598 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1L1PJK9
• Locus tag: Q5W_RS23350
• Protein ID: WP_009520269.1
• Coordinates: 4909015..4909347 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q5W_RS23340	4904749..4905840	+	1092	WP_009520271.1	efflux RND transporter periplasmic adaptor subunit	-
Q5W_RS23345	4905849..4909004	+	3156	WP_009520270.1	efflux RND transporter permease subunit	-
Q5W_RS23350	4909015..4909347	-	333	WP_009520269.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Q5W_RS23355	4909344..4909598	-	255	WP_035622005.1	type II toxin-antitoxin system HicA family toxin	Toxin
Q5W_RS23360	4909722..4911470	-	1749	WP_009520268.1	carboxylesterase family protein	-
Q5W_RS23365	4911627..4912577	+	951	WP_009520267.1	LysR family transcriptional regulator	-
Q5W_RS23370	4912593..4913429	-	837	WP_009520266.1	NmrA family NAD(P)-binding protein	-
Q5W_RS23375	4913571..4914560	+	990	WP_035622002.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.83 Da
• Isoelectric Point: 10.5889

>T66469 WP_035622005.1 NZ_CP017311:c4909598-4909344 [Hydrogenophaga sp. PBC]
VKRSHERTLEQLWAHPVSANLAWKDIEALFRALGADISEREGSRVAVVLFGEVKVFHRPHPSPHTDKGAVASVRRWLEQH
GVKP

Nucleotide

• Length: 255 bp

>T66469 NZ_CP017311:c4909598-4909344 [Hydrogenophaga sp. PBC]
GTGAAGCGCAGCCACGAACGCACGCTGGAGCAGCTCTGGGCCCATCCGGTCAGCGCGAACCTCGCCTGGAAGGACATCGA
AGCGCTGTTTCGAGCCTTGGGTGCCGATATATCGGAACGAGAAGGCAGCCGGGTGGCCGTGGTGCTCTTTGGCGAAGTGA
AGGTGTTTCATCGACCCCATCCTTCGCCGCACACAGACAAGGGAGCGGTGGCCAGCGTCAGGCGCTGGCTGGAACAACAC
GGAGTGAAACCATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12461.10 Da
• Isoelectric Point: 6.9835

>AT66469 WP_009520269.1 NZ_CP017311:c4909347-4909015 [Hydrogenophaga sp. PBC]
MNVMTVDGYQARIEYDAETDQFRGEILGLNGGADFYGRNPKELRAEFRKSLAVFLEVCREKGIEPRRSYSGRFNLRIPAE
LHERLAIVAQAEGKSINTVAQEALQQRLTA

Nucleotide

• Length: 333 bp

>AT66469 NZ_CP017311:c4909347-4909015 [Hydrogenophaga sp. PBC]
ATGAACGTCATGACCGTTGATGGCTATCAGGCCCGAATCGAGTACGACGCCGAGACCGACCAGTTTCGCGGCGAAATCCT
CGGCCTCAACGGCGGCGCCGATTTTTACGGCCGCAACCCGAAGGAACTGCGGGCGGAGTTCCGCAAGTCCCTCGCCGTGT
TCCTGGAAGTCTGCCGAGAGAAAGGCATCGAGCCCCGTCGCAGCTACTCGGGCAGGTTCAACCTGCGCATCCCGGCCGAA
CTGCACGAGCGCCTGGCCATCGTGGCGCAGGCCGAGGGCAAAAGCATCAACACGGTGGCGCAGGAGGCATTGCAGCAAAG
GCTCACCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1L1PJK9