Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 670764..671431 Replicon chromosome
Accession NZ_CP017311
Organism Hydrogenophaga sp. PBC

Toxin (Protein)


Gene name vapB Uniprot ID A0A1L1PKI9
Locus tag Q5W_RS03310 Protein ID WP_009517865.1
Coordinates 671018..671431 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L1PZ69
Locus tag Q5W_RS03305 Protein ID WP_009517864.1
Coordinates 670764..671021 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5W_RS03285 666896..668026 - 1131 WP_148663147.1 hypothetical protein -
Q5W_RS03290 668040..668309 - 270 WP_009517861.1 acyl carrier protein -
Q5W_RS03295 668330..669364 - 1035 WP_009517862.1 ketoacyl-ACP synthase III -
Q5W_RS03300 669615..670703 + 1089 WP_009517863.1 PA0069 family radical SAM protein -
Q5W_RS03305 670764..671021 + 258 WP_009517864.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Q5W_RS03310 671018..671431 + 414 WP_009517865.1 type II toxin-antitoxin system VapC family toxin Toxin
Q5W_RS03315 671412..672377 - 966 WP_009517867.1 pyridoxamine 5'-phosphate oxidase family protein -
Q5W_RS03320 672391..673059 - 669 WP_009517869.1 glutathione S-transferase -
Q5W_RS03325 673183..674091 + 909 WP_069902730.1 LysR family transcriptional regulator -
Q5W_RS25125 674104..674559 - 456 WP_084462927.1 DUF1653 domain-containing protein -
Q5W_RS03335 674605..675393 - 789 WP_069902731.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-128)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15444.72 Da        Isoelectric Point: 5.9138

>T66462 WP_009517865.1 NZ_CP017311:671018-671431 [Hydrogenophaga sp. PBC]
VSYLIDTNVLSELRKRQPDARVVAWMEARPPSTLYLSVLTLGEIRRGVEAMADSRRRLELLDWLETQLPAWFAGRVLGID
GETADRWGRLLAKAGRPLPGIDSLLAATAQRHGLQLVTRNVDDFRDVDVSLINPWVE

Download         Length: 414 bp

>T66462 NZ_CP017311:671018-671431 [Hydrogenophaga sp. PBC]
GTGAGTTATCTCATTGATACGAACGTACTGTCGGAACTGCGCAAGCGACAACCGGATGCGCGTGTGGTGGCCTGGATGGA
AGCCCGTCCGCCGAGCACGCTGTACCTGAGCGTGCTCACACTGGGCGAGATCCGGAGAGGCGTGGAAGCCATGGCCGATT
CGCGCAGGCGACTGGAACTCCTGGATTGGTTGGAGACGCAACTGCCGGCCTGGTTTGCCGGGCGCGTGCTGGGAATCGAT
GGCGAGACAGCGGATCGTTGGGGGCGGTTGCTCGCGAAGGCAGGCCGTCCGCTTCCGGGCATCGACAGCCTGCTGGCGGC
CACGGCTCAGCGGCACGGTCTTCAACTCGTGACGCGCAATGTCGACGACTTCCGCGATGTCGATGTCTCTCTGATCAATC
CCTGGGTGGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9444.77 Da        Isoelectric Point: 7.2044

>AT66462 WP_009517864.1 NZ_CP017311:670764-671021 [Hydrogenophaga sp. PBC]
MRAWQMQDAKARLSEVVKTARQQGPQDISVHGKTVAVLVSKEDFDRMSGRHLSLPAFIAASPLAEAAGEFELPPRLKDTP
KTEDW

Download         Length: 258 bp

>AT66462 NZ_CP017311:670764-671021 [Hydrogenophaga sp. PBC]
ATGAGGGCATGGCAAATGCAGGACGCCAAGGCGCGCCTGTCCGAAGTGGTGAAGACGGCCCGCCAGCAAGGGCCGCAAGA
CATCAGCGTGCACGGCAAAACGGTGGCGGTTCTGGTGTCGAAGGAAGACTTCGACCGCATGAGCGGGCGGCATCTCAGCC
TTCCGGCCTTCATCGCGGCGTCGCCGCTGGCCGAAGCGGCGGGTGAATTCGAACTCCCGCCGCGCTTGAAGGACACGCCG
AAGACGGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L1PKI9

Antitoxin

Source ID Structure
AlphaFold DB A0A1L1PZ69

References