Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2266747..2267579 Replicon chromosome
Accession NZ_CP017220
Organism Escherichia coli strain FAM21845

Toxin (Protein)


Gene name yeeV Uniprot ID A0A4D0PXM5
Locus tag BHT24_RS12055 Protein ID WP_042966690.1
Coordinates 2267205..2267579 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag BHT24_RS12050 Protein ID WP_001295723.1
Coordinates 2266747..2267115 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHT24_RS12010 2263862..2264020 + 159 WP_001323397.1 DUF905 family protein -
BHT24_RS12020 2264175..2264993 + 819 WP_001765427.1 DUF945 domain-containing protein -
BHT24_RS12030 2265335..2265808 + 474 WP_001765426.1 antirestriction protein -
BHT24_RS12035 2265824..2266300 + 477 WP_001186775.1 RadC family protein -
BHT24_RS12040 2266363..2266584 + 222 WP_000692345.1 DUF987 domain-containing protein -
BHT24_RS12050 2266747..2267115 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BHT24_RS12055 2267205..2267579 + 375 WP_042966690.1 TA system toxin CbtA family protein Toxin
BHT24_RS12060 2267576..2267782 + 207 WP_000976829.1 hypothetical protein -
BHT24_RS28015 2267795..2267908 + 114 WP_001161660.1 DUF957 domain-containing protein -
BHT24_RS28120 2268624..2268764 + 141 WP_001342279.1 hypothetical protein -
BHT24_RS28125 2268724..2269095 + 372 WP_001445978.1 IS110 family transposase -
BHT24_RS12070 2269433..2270455 + 1023 WP_000255946.1 IS21-like element IS100 family transposase -
BHT24_RS12075 2270452..2271234 + 783 WP_001317493.1 IS21-like element IS100kyp family helper ATPase IstB -
BHT24_RS27830 2271508..2271690 + 183 WP_001667686.1 ethanolamine utilization - propanediol utilization family protein -
BHT24_RS12085 2271791..2272120 - 330 WP_000450409.1 DUF496 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14075.10 Da        Isoelectric Point: 6.8429

>T66239 WP_042966690.1 NZ_CP017220:2267205-2267579 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDEHVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T66239 NZ_CP017220:2267205-2267579 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACACGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT66239 WP_001295723.1 NZ_CP017220:2266747-2267115 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT66239 NZ_CP017220:2266747-2267115 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D0PXM5

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References