Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5292621..5293288 Replicon chromosome
Accession NZ_CP017188
Organism Xanthomonas citri pv. glycines str. 8ra

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag BHE84_RS24005 Protein ID WP_005916679.1
Coordinates 5292872..5293288 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag BHE84_RS24000 Protein ID WP_005916676.1
Coordinates 5292621..5292875 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHE84_RS23975 5288727..5288936 + 210 WP_108350128.1 RNA 2'-phosphotransferase -
BHE84_RS23980 5289119..5290384 + 1266 WP_016849472.1 cardiolipin synthase B -
BHE84_RS23985 5290410..5290937 - 528 WP_005916668.1 hypothetical protein -
BHE84_RS23990 5291176..5291382 + 207 WP_003489327.1 hypothetical protein -
BHE84_RS23995 5291369..5292475 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
BHE84_RS24000 5292621..5292875 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
BHE84_RS24005 5292872..5293288 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
BHE84_RS24010 5293410..5293622 - 213 WP_160300355.1 hypothetical protein -
BHE84_RS24015 5293695..5293955 - 261 WP_124632112.1 hypothetical protein -
BHE84_RS24020 5294212..5295831 + 1620 WP_016849230.1 enterochelin esterase -
BHE84_RS24025 5295935..5296333 - 399 WP_004429277.1 DUF2384 domain-containing protein -
BHE84_RS24030 5296649..5297080 + 432 WP_016849229.1 hypothetical protein -
BHE84_RS24035 5297109..5297435 - 327 Protein_4455 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T66216 WP_005916679.1 NZ_CP017188:5292872-5293288 [Xanthomonas citri pv. glycines str. 8ra]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T66216 NZ_CP017188:5292872-5293288 [Xanthomonas citri pv. glycines str. 8ra]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAAGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT66216 WP_005916676.1 NZ_CP017188:5292621-5292875 [Xanthomonas citri pv. glycines str. 8ra]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT66216 NZ_CP017188:5292621-5292875 [Xanthomonas citri pv. glycines str. 8ra]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References