Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1024063..1024598 Replicon chromosome
Accession NZ_CP017069
Organism Staphylococcus lugdunensis strain K93G

Toxin (Protein)


Gene name TscT Uniprot ID C5QLS6
Locus tag BFP67_RS04830 Protein ID WP_002445368.1
Coordinates 1024275..1024598 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID C5QLS5
Locus tag BFP67_RS04825 Protein ID WP_001058489.1
Coordinates 1024063..1024272 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFP67_RS04790 1019319..1019603 + 285 WP_002461410.1 co-chaperone GroES -
BFP67_RS04795 1019663..1021285 + 1623 WP_002461409.1 chaperonin GroEL -
BFP67_RS04800 1021354..1022526 - 1173 WP_002492309.1 site-specific integrase -
BFP67_RS04805 1022540..1023214 - 675 WP_002445345.1 helix-turn-helix transcriptional regulator -
BFP67_RS04810 1023387..1023605 + 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
BFP67_RS04815 1023610..1023927 + 318 WP_002445364.1 helix-turn-helix domain-containing protein -
BFP67_RS04820 1023924..1024070 + 147 WP_002445365.1 hypothetical protein -
BFP67_RS04825 1024063..1024272 + 210 WP_001058489.1 hypothetical protein Antitoxin
BFP67_RS04830 1024275..1024598 + 324 WP_002445368.1 DUF1474 family protein Toxin
BFP67_RS04835 1024662..1025531 + 870 WP_002445370.1 primase alpha helix C-terminal domain-containing protein -
BFP67_RS04840 1025545..1027254 + 1710 WP_002445371.1 DUF927 domain-containing protein -
BFP67_RS04845 1027602..1027967 + 366 WP_002445372.1 hypothetical protein -
BFP67_RS04850 1027981..1028622 + 642 WP_002492310.1 pathogenicity island protein -
BFP67_RS04855 1028910..1029254 + 345 WP_094449183.1 pathogenicity island protein -
BFP67_RS04860 1029268..1029501 + 234 WP_002492317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 1015750..1034736 18986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 13107.51 Da        Isoelectric Point: 4.8571

>T65857 WP_002445368.1 NZ_CP017069:1024275-1024598 [Staphylococcus lugdunensis]
MNWEIKNLFSDLKLLKDSFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIQ
KFHELEKASSENFGEESDDAQKLKITE

Download         Length: 324 bp

>T65857 NZ_CP017069:1024275-1024598 [Staphylococcus lugdunensis]
ATGAATTGGGAAATTAAAAATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGTTATATCCACATGAACCAAATCATAACTTAAATAAAGATGAATTAATTAGAGAGGGTTTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAACAGTTCGATAAAATTATACAA
AAGTTTCATGAATTAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGA
GTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8225.24 Da        Isoelectric Point: 4.2820

>AT65857 WP_001058489.1 NZ_CP017069:1024063-1024272 [Staphylococcus lugdunensis]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT65857 NZ_CP017069:1024063-1024272 [Staphylococcus lugdunensis]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A853V601

References