Detailed information of TA system TA065603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2306262..2307222
• Replicon: chromosome
• Accession: NZ_CP016945
• Organism: Yersinia enterocolitica strain YE1

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A7U7FM81
• Locus tag: BFS78_RS11050
• Protein ID: WP_013649871.1
• Coordinates: 2306262..2306720 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7U7FM48
• Locus tag: BFS78_RS11055
• Protein ID: WP_013649872.1
• Coordinates: 2306776..2307222 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFS78_RS11020	2302077..2302742	+	666	WP_005161029.1	phage shock protein PspA	-
BFS78_RS11025	2302904..2303131	+	228	WP_005161022.1	envelope stress response membrane protein PspB	-
BFS78_RS11030	2303131..2303535	+	405	WP_013649869.1	envelope stress response membrane protein PspC	-
BFS78_RS11035	2303581..2303820	+	240	WP_005161016.1	phage shock protein PspD	-
BFS78_RS11040	2303801..2305198	+	1398	WP_050158954.1	YcjX family protein	-
BFS78_RS11045	2305195..2306259	+	1065	WP_049526682.1	YcjF family protein	-
BFS78_RS11050	2306262..2306720	-	459	WP_013649871.1	RES family NAD+ phosphorylase	Toxin
BFS78_RS11055	2306776..2307222	-	447	WP_013649872.1	DUF2384 domain-containing protein	Antitoxin
BFS78_RS11060	2307542..2309119	+	1578	WP_020283144.1	transcriptional regulator TyrR	-
BFS78_RS11065	2309366..2309869	-	504	WP_005161000.1	thiol peroxidase	-
BFS78_RS11070	2310022..2310993	+	972	WP_049526684.1	L-Ala-D/L-Glu epimerase	-
BFS78_RS11075	2310990..2311697	-	708	WP_005160995.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17158.54 Da
• Isoelectric Point: 4.6717

>T65603 WP_013649871.1 NZ_CP016945:c2306720-2306262 [Yersinia enterocolitica]
MILYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTNWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPQHKSFQACLSSVQPLSFAFDPRLK

Nucleotide

• Length: 459 bp

>T65603 NZ_CP016945:c2306720-2306262 [Yersinia enterocolitica]
ATGATACTCTACCGCATCGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAACCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACATTGGTACATATTC
AGGACAGCTCAACACTGAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAA
GATTGGCCCACGAACTGGCGTAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAATCAGAATC
ATCACTCGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTGCTGCTCAACCCTCAACACAAAAGTTTTC
AAGCCTGTTTAAGCAGTGTTCAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16322.77 Da
• Isoelectric Point: 9.8753

>AT65603 WP_013649872.1 NZ_CP016945:c2307222-2306776 [Yersinia enterocolitica]
MRAYHPTPATKTRALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLVGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT65603 NZ_CP016945:c2307222-2306776 [Yersinia enterocolitica]
ATGAGAGCATATCACCCCACTCCAGCGACTAAAACAAGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATTCATCTATGGGCATCTATTCCAAAAG
CTGAAATCTTGCGTGCGACCGGTATTCCCAGCCGTAGCTTGACCCGCAGACGCACCCATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGCATTGCGCGCTTCGTGCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGCCACCGTAGTCCGGATTCCTTACTGGAAACTGAAACCGGTGCATTGG
AAGTCTGTGATTTGGTTGGACGCCTGGAGCACGGCGTATTTTCATAA

Structures

Toxin

• AlphaFold DB: A0A7U7FM81

Antitoxin

• AlphaFold DB: A0A7U7FM48