Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4459727..4460370 Replicon chromosome
Accession NZ_CP016944
Organism Yersinia enterocolitica strain YE3

Toxin (Protein)


Gene name vagD Uniprot ID A0A7U7IT36
Locus tag BED35_RS21560 Protein ID WP_005161957.1
Coordinates 4459727..4460146 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E1NFG4
Locus tag BED35_RS21565 Protein ID WP_005161959.1
Coordinates 4460143..4460370 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BED35_RS21540 4454946..4455800 + 855 WP_005178323.1 formate dehydrogenase accessory sulfurtransferase FdhD -
BED35_RS21545 4455927..4456550 + 624 WP_013650637.1 superoxide dismutase [Mn] -
BED35_RS21550 4456874..4458823 + 1950 WP_057618828.1 methyl-accepting chemotaxis protein -
BED35_RS21555 4458902..4459573 + 672 WP_049525202.1 6-N-hydroxylaminopurine resistance protein -
BED35_RS21560 4459727..4460146 - 420 WP_005161957.1 type II toxin-antitoxin system VapC family toxin Toxin
BED35_RS21565 4460143..4460370 - 228 WP_005161959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BED35_RS21570 4460502..4460858 - 357 WP_005161962.1 YibL family ribosome-associated protein -
BED35_RS21575 4460951..4462432 - 1482 WP_049525201.1 PLP-dependent aminotransferase family protein -
BED35_RS21580 4462700..4463311 + 612 WP_013650641.1 LysE family translocator -
BED35_RS21585 4463308..4463862 - 555 WP_020283571.1 MltR family transcriptional regulator -
BED35_RS21590 4464093..4465256 - 1164 WP_013650643.1 mannitol-1-phosphate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15582.17 Da        Isoelectric Point: 9.0596

>T65598 WP_005161957.1 NZ_CP016944:c4460146-4459727 [Yersinia enterocolitica]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDT
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Download         Length: 420 bp

>T65598 NZ_CP016944:c4460146-4459727 [Yersinia enterocolitica]
ATGATCAAAAAATTATATATGCTTGATACGAATATTTGTTCTTTTATTATGCGGGAACGACCAGCAGAATTAATTATAAA
ATTACAACAGTGTATTGAGCATCAGAATAAAATAGTTGTTTCAGCAATTACATACTCAGAAATGCGGTTTGGCGCTATAG
GTAAGAAAGCATCTCCAAAGCATAATTATTTAGTTGATGAATTTGTAAAAAGGTTAGATGCTATTTTACCGTGGGATACC
GCAGCTGTTGATGCCACGACTAATATTAAGGTTGAGCTGGCAAAGCAGGGGACACCAATTGGTGGAAATGATGCCGCAAT
AGCCGGGCACGCAGTTTCTGCTGGAGCAATATTAGTCACTAATAATATTAGAGAGTTTGAACGAGTTAAAAAACTACGAA
TTGAAGATTGGACTCAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.91 Da        Isoelectric Point: 4.1971

>AT65598 WP_005161959.1 NZ_CP016944:c4460370-4460143 [Yersinia enterocolitica]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp

>AT65598 NZ_CP016944:c4460370-4460143 [Yersinia enterocolitica]
ATGAGAACGGTATCTATTTTCAAAAATGGGCAGAATCGAGCAATTCGTTTGCCAAAAGATATGGATTTTGATGGCGTGAC
CGAGCTGGAAATACTCAGAGACGGTGATAGTATTATTTTACGACCCATACGCCCGACATGGGTATCATTCATGGATGAAG
ATAAGGCAGATGATGATTTTCTTGCCGAAAGACAGGATGTTATCGAAGAAGGACGCTTCGAGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IT36

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NFG4

References