Detailed information of TA system TA065585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2303411..2304371
• Replicon: chromosome
• Accession: NZ_CP016944
• Organism: Yersinia enterocolitica strain YE3

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A7U7FM81
• Locus tag: BED35_RS11965
• Protein ID: WP_013649871.1
• Coordinates: 2303411..2303869 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7U7FM48
• Locus tag: BED35_RS11970
• Protein ID: WP_013649872.1
• Coordinates: 2303925..2304371 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BED35_RS11935	2299226..2299891	+	666	WP_005161029.1	phage shock protein PspA	-
BED35_RS11940	2300053..2300280	+	228	WP_005161022.1	envelope stress response membrane protein PspB	-
BED35_RS11945	2300280..2300684	+	405	WP_013649869.1	envelope stress response membrane protein PspC	-
BED35_RS11950	2300730..2300969	+	240	WP_005161016.1	phage shock protein PspD	-
BED35_RS11955	2300950..2302347	+	1398	WP_050158954.1	YcjX family protein	-
BED35_RS11960	2302344..2303408	+	1065	WP_049526682.1	YcjF family protein	-
BED35_RS11965	2303411..2303869	-	459	WP_013649871.1	RES family NAD+ phosphorylase	Toxin
BED35_RS11970	2303925..2304371	-	447	WP_013649872.1	DUF2384 domain-containing protein	Antitoxin
BED35_RS11975	2304691..2306268	+	1578	WP_020283144.1	transcriptional regulator TyrR	-
BED35_RS11980	2306515..2307018	-	504	WP_005161000.1	thiol peroxidase	-
BED35_RS11985	2307171..2308142	+	972	WP_049526684.1	L-Ala-D/L-Glu epimerase	-
BED35_RS11990	2308139..2308846	-	708	WP_005160995.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17158.54 Da
• Isoelectric Point: 4.6717

>T65585 WP_013649871.1 NZ_CP016944:c2303869-2303411 [Yersinia enterocolitica]
MILYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTNWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPQHKSFQACLSSVQPLSFAFDPRLK

Nucleotide

• Length: 459 bp

>T65585 NZ_CP016944:c2303869-2303411 [Yersinia enterocolitica]
ATGATACTCTACCGCATCGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAACCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACATTGGTACATATTC
AGGACAGCTCAACACTGAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAA
GATTGGCCCACGAACTGGCGTAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAATCAGAATC
ATCACTCGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTGCTGCTCAACCCTCAACACAAAAGTTTTC
AAGCCTGTTTAAGCAGTGTTCAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16322.77 Da
• Isoelectric Point: 9.8753

>AT65585 WP_013649872.1 NZ_CP016944:c2304371-2303925 [Yersinia enterocolitica]
MRAYHPTPATKTRALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLVGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT65585 NZ_CP016944:c2304371-2303925 [Yersinia enterocolitica]
ATGAGAGCATATCACCCCACTCCAGCGACTAAAACAAGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATTCATCTATGGGCATCTATTCCAAAAG
CTGAAATCTTGCGTGCGACCGGTATTCCCAGCCGTAGCTTGACCCGCAGACGCACCCATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGCATTGCGCGCTTCGTGCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGCCACCGTAGTCCGGATTCCTTACTGGAAACTGAAACCGGTGCATTGG
AAGTCTGTGATTTGGTTGGACGCCTGGAGCACGGCGTATTTTCATAA

Structures

Toxin

• AlphaFold DB: A0A7U7FM81

Antitoxin

• AlphaFold DB: A0A7U7FM48