Detailed information of TA system TA065558

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 4381868..4382592
• Replicon: chromosome
• Accession: NZ_CP016937
• Organism: Yersinia enterocolitica strain YE6

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A7U7FJ92
• Locus tag: BED33_RS20380
• Protein ID: WP_005166025.1
• Coordinates: 4382296..4382592 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A7U7IZK5
• Locus tag: BED33_RS20375
• Protein ID: WP_049527936.1
• Coordinates: 4381868..4382296 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BED33_RS20350	4377187..4378431	-	1245	WP_049527926.1	sensor domain-containing diguanylate cyclase	-
BED33_RS20355	4378514..4378909	-	396	WP_005166615.1	SgcJ/EcaC family oxidoreductase	-
BED33_RS20360	4379281..4380228	-	948	Protein_3981	Fic family protein	-
BED33_RS20365	4380246..4380446	+	201	WP_049527931.1	AlpA family transcriptional regulator	-
BED33_RS20370	4380589..4381791	+	1203	WP_049527934.1	IS256 family transposase	-
BED33_RS20375	4381868..4382296	-	429	WP_049527936.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BED33_RS20380	4382296..4382592	-	297	WP_005166025.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BED33_RS20385	4382749..4383111	-	363	WP_005166026.1	helix-turn-helix domain-containing protein	-
BED33_RS20390	4383177..4383437	-	261	WP_005166028.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BED33_RS20395	4383934..4384965	-	1032	Protein_3988	IS630 family transposase	-
BED33_RS20400	4385521..4386741	+	1221	WP_049527941.1	tyrosine-type recombinase/integrase	-
BED33_RS20405	4386817..4387191	-	375	WP_049527943.1	hypothetical protein	-
BED33_RS20410	4387188..4387397	-	210	WP_049527946.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	4375749..4384965	9216

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (4-132)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11322.18 Da
• Isoelectric Point: 7.7766

>T65558 WP_005166025.1 NZ_CP016937:c4382592-4382296 [Yersinia enterocolitica]
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T65558 NZ_CP016937:c4382592-4382296 [Yersinia enterocolitica]
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 16029.82 Da
• Isoelectric Point: 9.1221

>AT65558 WP_049527936.1 NZ_CP016937:c4382296-4381868 [Yersinia enterocolitica]
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIRWLFGVRYFLM

Nucleotide

• Length: 429 bp

>AT65558 NZ_CP016937:c4382296-4381868 [Yersinia enterocolitica]
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGATCAACGATAAAATTGTTGCAAGTGCTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTGGT
TGTTTGGGGTAAGATACTTTTTAATGTGA

Structures

Toxin

• AlphaFold DB: A0A7U7FJ92

Antitoxin

• AlphaFold DB: A0A7U7IZK5