Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 53295..53893 Replicon plasmid unnamed
Accession NZ_CP016869
Organism Legionella pneumophila subsp. pneumophila strain FFI102

Toxin (Protein)


Gene name hicA Uniprot ID Q5WRX3
Locus tag BE841_RS15155 Protein ID WP_011212625.1
Coordinates 53696..53893 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q5WRX4
Locus tag BE841_RS15150 Protein ID WP_011212624.1
Coordinates 53295..53699 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE841_RS15140 49436..52384 + 2949 WP_070322516.1 conjugative relaxase -
BE841_RS15145 52401..52724 + 324 WP_011212623.1 hypothetical protein -
BE841_RS15150 53295..53699 - 405 WP_011212624.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BE841_RS15155 53696..53893 - 198 WP_011212625.1 type II toxin-antitoxin system HicA family toxin Toxin
BE841_RS15160 54887..55636 + 750 WP_070322515.1 porin family protein -
BE841_RS15165 55647..57101 + 1455 WP_070322514.1 DUF1566 domain-containing protein -
BE841_RS15170 57175..57516 + 342 WP_019350429.1 four helix bundle protein -
BE841_RS15800 57488..57811 - 324 WP_070326930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..68145 68145


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7403.75 Da        Isoelectric Point: 10.6519

>T65314 WP_011212625.1 NZ_CP016869:c53893-53696 [Legionella pneumophila subsp. pneumophila]
MKSAEIIKIIERDGWVQCHQKGSHCQFKHPTKKGRVTVPHPKKDLPIKTVASIFKQAGINKEDIK

Download         Length: 198 bp

>T65314 NZ_CP016869:c53893-53696 [Legionella pneumophila subsp. pneumophila]
ATGAAAAGCGCAGAAATAATAAAAATAATTGAACGCGATGGATGGGTGCAATGTCATCAGAAAGGAAGTCATTGCCAATT
TAAACATCCCACCAAAAAGGGTAGGGTGACAGTACCTCATCCTAAAAAAGATTTACCTATAAAAACAGTGGCCAGTATCT
TTAAACAAGCTGGTATTAATAAGGAGGATATAAAATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15006.00 Da        Isoelectric Point: 4.5129

>AT65314 WP_011212624.1 NZ_CP016869:c53699-53295 [Legionella pneumophila subsp. pneumophila]
MRYPVVIHKDEHSDFGVIVPDIPGCYSSGSTYDEALTNVIEAIECHLEGLLIDNEPLPVGTTIDRWINDEEFQGGVWAFV
DIDLSQISGKAKRINITMPERILSLIDLYAKNHAIKNRSSFLADAALSYMESHK

Download         Length: 405 bp

>AT65314 NZ_CP016869:c53699-53295 [Legionella pneumophila subsp. pneumophila]
ATGAGATATCCTGTAGTAATACATAAAGACGAACATAGTGATTTTGGTGTAATTGTCCCTGATATTCCTGGATGCTATTC
TTCTGGTAGCACTTATGATGAAGCTTTAACTAACGTAATTGAGGCAATTGAATGCCATTTGGAAGGATTATTAATAGATA
ATGAGCCTCTTCCAGTTGGTACAACAATTGATCGATGGATTAATGATGAAGAGTTTCAGGGCGGGGTATGGGCATTTGTT
GACATTGATTTAAGCCAAATATCGGGTAAAGCAAAACGCATTAATATCACTATGCCAGAGCGCATTTTAAGTCTCATCGA
TCTGTATGCCAAAAACCATGCGATAAAAAATCGTTCCTCCTTTTTGGCCGATGCAGCTCTGAGTTATATGGAAAGTCATA
AGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0VJ23

Antitoxin

Source ID Structure
AlphaFold DB Q5WRX4

References