Detailed information of TA system TA065095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazF-pemI/MazF(toxin)
• Location: 3555683..3556318
• Replicon: chromosome
• Accession: NZ_CP016808
• Organism: Paenibacillus sp. BIHB4019

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: BBD42_RS15195
• Protein ID: WP_046233824.1
• Coordinates: 3555968..3556318 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: BBD42_RS15190
• Protein ID: WP_046233825.1
• Coordinates: 3555683..3555964 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBD42_RS15170	3551158..3552084	-	927	WP_099521623.1	ABC transporter substrate-binding protein	-
BBD42_RS15175	3552204..3552671	-	468	WP_099518832.1	MarR family transcriptional regulator	-
BBD42_RS15180	3552860..3554113	+	1254	WP_099518833.1	outer membrane lipoprotein carrier protein LolA	-
BBD42_RS15185	3554258..3555451	+	1194	WP_099518834.1	alanine racemase	-
BBD42_RS15190	3555683..3555964	+	282	WP_046233825.1	CopG family ribbon-helix-helix protein	Antitoxin
BBD42_RS15195	3555968..3556318	+	351	WP_046233824.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BBD42_RS15200	3556672..3557397	+	726	WP_099518835.1	flagellar biosynthesis protein FlgA	-
BBD42_RS15205	3557397..3558242	+	846	WP_099518836.1	hypothetical protein	-
BBD42_RS15210	3558239..3559618	+	1380	WP_099518837.1	Flp pilus assembly complex ATPase component TadA	-
BBD42_RS15215	3559668..3560546	+	879	WP_099521624.1	type II secretion system F family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12764.75 Da
• Isoelectric Point: 5.6126

>T65095 WP_046233824.1 NZ_CP016808:3555968-3556318 [Paenibacillus sp. BIHB4019]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEMNAAAHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDDETMRKVDDALLISVGLIDF

Nucleotide

• Length: 351 bp

>T65095 NZ_CP016808:3555968-3556318 [Paenibacillus sp. BIHB4019]
TTGATCGTAAAACGTGGAGACGTGTTCTTTGCTGATCTGTCACCTGTCGTCGGATCGGAGCAGGGAGGAGTGCGGCCTGT
TCTTGTCATTCAGAATGATATCGGCAACCGGTTTAGTCCGACCGTCATTGTGGCGGCCATTACCGCGCAGATTCAGAAGG
CGAAGCTCCCTACACATGTAGAAATGAACGCGGCTGCACATGGCTTTGACCGGGATTCCGTCGTTCTGCTTGAGCAGATT
CGAACGATCGACAAACAGCGGCTGACCGACAAAATTACGCATTTGGACGATGAAACGATGCGTAAGGTCGATGATGCGCT
ATTGATTAGTGTAGGCCTGATTGATTTTTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10658.29 Da
• Isoelectric Point: 8.5755

>AT65095 WP_046233825.1 NZ_CP016808:3555683-3555964 [Paenibacillus sp. BIHB4019]
VANVQNTKRIMISLPDHLLEEVDGIVAKENSNRSEFIRQAMKLYLVERKKRQIRESMQRGYLEMAKINLNMASEAFQAEV
EADHTLGRLVSGV

Nucleotide

• Length: 282 bp

>AT65095 NZ_CP016808:3555683-3555964 [Paenibacillus sp. BIHB4019]
GTGGCCAATGTGCAGAACACCAAGAGGATCATGATTAGCTTGCCGGATCATTTACTGGAGGAGGTTGACGGTATCGTAGC
TAAGGAGAACTCTAACCGCAGTGAATTTATTAGGCAGGCTATGAAGCTGTACCTTGTGGAAAGAAAGAAACGGCAAATCC
GCGAGTCCATGCAGCGTGGGTATCTGGAGATGGCGAAAATCAACTTGAACATGGCCTCGGAAGCTTTTCAAGCGGAGGTA
GAGGCTGATCACACGCTCGGCCGTCTTGTAAGCGGGGTGTAG