Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HipB
Location 570475..571136 Replicon chromosome
Accession NZ_CP016757
Organism Cloacibacillus porcorum strain CL-84 (T)

Toxin (Protein)


Gene name higB Uniprot ID A0A1B2I264
Locus tag BED41_RS02565 Protein ID WP_066742729.1
Coordinates 570768..571136 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B2I274
Locus tag BED41_RS02560 Protein ID WP_066742727.1
Coordinates 570475..570765 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BED41_RS02545 566141..569938 + 3798 WP_168160217.1 autotransporter outer membrane beta-barrel domain-containing protein -
BED41_RS02560 570475..570765 - 291 WP_066742727.1 helix-turn-helix domain-containing protein Antitoxin
BED41_RS02565 570768..571136 - 369 WP_066742729.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BED41_RS02570 571424..572815 + 1392 WP_066748854.1 PQQ-dependent sugar dehydrogenase -
BED41_RS02575 573280..574218 + 939 WP_066742731.1 bile acid:sodium symporter family protein -
BED41_RS02580 574419..575312 + 894 WP_066742744.1 ParB N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-89)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14463.53 Da        Isoelectric Point: 8.3883

>T65023 WP_066742729.1 NZ_CP016757:c571136-570768 [Cloacibacillus porcorum]
MYEIIFYSDKNGREPVADYMQELGKSKTKDNRVKHNKISQYIKVLSEVGTMAGMPYMRHLEGEIWELRPIRDRILFAGFV
DGTFILLHSFMKQSQKTPPEEIAQAKRELEDFRTRYNSNREE

Download         Length: 369 bp

>T65023 NZ_CP016757:c571136-570768 [Cloacibacillus porcorum]
TTGTATGAAATAATCTTTTACAGCGACAAAAACGGCAGGGAGCCTGTAGCTGACTATATGCAGGAGCTGGGAAAGAGCAA
GACAAAAGACAACCGTGTCAAGCATAACAAGATTTCACAGTATATCAAGGTTTTATCAGAGGTTGGAACGATGGCCGGCA
TGCCGTACATGCGACATCTGGAGGGTGAAATCTGGGAGTTACGACCAATCCGCGATCGCATTTTATTTGCCGGTTTCGTA
GATGGGACGTTCATTTTGCTTCATTCATTCATGAAGCAGTCACAGAAAACGCCGCCAGAAGAAATTGCGCAGGCAAAAAG
AGAGTTAGAGGATTTCAGGACAAGATATAACAGCAACAGGGAGGAATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10924.60 Da        Isoelectric Point: 5.1633

>AT65023 WP_066742727.1 NZ_CP016757:c570765-570475 [Cloacibacillus porcorum]
MVYKNGFRVWDEEFERELYTSEEIQENNIQAQLMCELIRARQEKNVSQRDLKEMTGIAQSTIARIESGATVPSLTTLIKI
LAPLGKTLAIVPITKN

Download         Length: 291 bp

>AT65023 NZ_CP016757:c570765-570475 [Cloacibacillus porcorum]
ATGGTCTATAAAAACGGGTTCAGGGTGTGGGACGAAGAATTTGAGCGCGAACTGTATACATCGGAAGAGATACAAGAAAA
TAATATTCAGGCACAGCTTATGTGTGAGCTGATAAGGGCACGACAGGAGAAAAATGTCAGTCAAAGGGATTTGAAGGAAA
TGACCGGGATTGCCCAATCTACGATTGCGCGGATAGAAAGCGGTGCTACAGTTCCATCATTGACAACACTTATCAAGATA
TTGGCGCCTTTGGGAAAGACGTTGGCAATCGTTCCGATAACAAAGAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B2I264

Antitoxin

Source ID Structure
AlphaFold DB A0A1B2I274

References