Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 602565..603396 Replicon chromosome
Accession NZ_CP016497
Organism Escherichia coli strain UPEC 26-1

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag BB344_RS02695 Protein ID WP_000854814.1
Coordinates 602565..602939 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag BB344_RS02700 Protein ID WP_001285586.1
Coordinates 603028..603396 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB344_RS02660 597961..599127 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
BB344_RS02665 599246..599719 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
BB344_RS02670 599917..600975 + 1059 WP_001200890.1 FUSC family protein -
BB344_RS02675 601147..601476 + 330 WP_000450409.1 DUF496 family protein -
BB344_RS02680 601577..601759 - 183 WP_001016348.1 hypothetical protein -
BB344_RS26595 601813..601959 + 147 Protein_518 transposase domain-containing protein -
BB344_RS29555 602248..602361 - 114 WP_001161660.1 DUF957 domain-containing protein -
BB344_RS02690 602374..602568 - 195 WP_000988601.1 hypothetical protein -
BB344_RS02695 602565..602939 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
BB344_RS02700 603028..603396 - 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BB344_RS02705 603470..603691 - 222 WP_000692323.1 DUF987 domain-containing protein -
BB344_RS02710 603760..604236 - 477 WP_001351157.1 RadC family protein -
BB344_RS02715 604252..604737 - 486 WP_000213703.1 antirestriction protein -
BB344_RS02720 604828..605649 - 822 WP_001234569.1 DUF945 domain-containing protein -
BB344_RS02725 605870..606280 - 411 WP_000846704.1 hypothetical protein -
BB344_RS02730 606296..606973 - 678 WP_001362823.1 hypothetical protein -
BB344_RS02735 607109..608179 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T64696 WP_000854814.1 NZ_CP016497:c602939-602565 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T64696 NZ_CP016497:c602939-602565 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT64696 WP_001285586.1 NZ_CP016497:c603396-603028 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT64696 NZ_CP016497:c603396-603028 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References