Detailed information of TA system TA064561

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF4/-
• Location: 1991303..1991602
• Replicon: chromosome
• Accession: NZ_CP016398
• Organism: Staphylococcus aureus strain FORC_040

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FORC40_RS10110
• Protein ID: WP_011447039.1
• Coordinates: 1991426..1991602 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	1991303..1991358 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC40_RS10050	1986645..1986905	+	261	WP_001791826.1	hypothetical protein	-
FORC40_RS10055	1986958..1987298	-	341	Protein_1855	complement inhibitor SCIN-A	-
FORC40_RS10065	1987982..1988431	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
FORC40_RS14285	1988526..1988861	-	336	Protein_1857	SH3 domain-containing protein	-
FORC40_RS10090	1989511..1990002	-	492	WP_000919350.1	staphylokinase	-
FORC40_RS10095	1990193..1990948	-	756	WP_000861038.1	CHAP domain-containing protein	-
FORC40_RS10100	1990960..1991214	-	255	WP_000611512.1	phage holin	-
FORC40_RS10105	1991266..1991373	+	108	WP_001791821.1	hypothetical protein	-
-	1991295..1991434	+	140	NuclAT_0	-	-
-	1991295..1991434	+	140	NuclAT_0	-	-
-	1991295..1991434	+	140	NuclAT_0	-	-
-	1991295..1991434	+	140	NuclAT_0	-	-
-	1991303..1991358	+	56	-	-	Antitoxin
FORC40_RS10110	1991426..1991602	-	177	WP_011447039.1	putative holin-like toxin	Toxin
FORC40_RS10115	1991752..1992048	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
FORC40_RS10120	1992106..1992393	-	288	WP_001040261.1	hypothetical protein	-
FORC40_RS10125	1992440..1992592	-	153	WP_001153681.1	hypothetical protein	-
FORC40_RS10130	1992582..1996367	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / scn / chp / sak / hlb / groEL	1986958..2039168	52210

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T64561 WP_011447039.1 NZ_CP016398:c1991602-1991426 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T64561 NZ_CP016398:c1991602-1991426 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT64561 NZ_CP016398:1991303-1991358 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin